Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease - Test2 - elhamkhani - TriplyDB

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

http://www.wikidata.org/entity/Q33616828

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Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease Memory loss in Alzheimer's disease Transcriptional signatures of brain aging and Alzheimer's disease: What are our rodent models telling us?Age-Related Gene Expression in the Frontal Cortex Suggests Synaptic Function Changes in Specific Inhibitory Neuron Subtypes.Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease.Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity.Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats.Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats.Gene Expression Switching of Receptor Subunits in Human Brain Development.Inverse correlation between Alzheimer's disease and cancer: implication for a strong impact of regenerative propensity on neurodegeneration?Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons.Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging.Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment.Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders.Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease.Memory impairment in aged primates is associated with region-specific network dysfunction.Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology.Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex.Sleep and immune function: glial contributions and consequences of aging Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.Neurotrophin signalling: novel insights into mechanisms and pathophysiology.Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment.Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease.Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease.Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole Mente Activa® Improves Impaired Spatial Memory in Aging Rats.Identification of Biomarkers Associated With Alzheimer's Disease by Bioinformatics Analysis.DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment.Transcriptional Analysis of Blood Lymphocytes and Skin Fibroblasts, Keratinocytes, and Endothelial Cells as a Potential Biomarker for Alzheimer's Disease.Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function.Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer's disease.3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging.Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan.The Bioinformatic Analysis of the Dysregulated Genes and MicroRNAs in Entorhinal Cortex, Hippocampus, and Blood for Alzheimer's Disease.Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer's disease at various cognitive stages.The Subcellular Distribution of Alpha-Tocopherol in the Adult Primate Brain and Its Relationship with Membrane Arachidonic Acid and Its Oxidation Products.Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease.

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Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

http://www.wikidata.org/entity/Q33616828

description

2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Synaptic genes are extensively ...... aging and Alzheimer's disease

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Synaptic genes are extensively ...... aging and Alzheimer's disease

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Synaptic genes are extensively ...... aging and Alzheimer's disease

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Synaptic genes are extensively ...... aging and Alzheimer's disease

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Synaptic genes are extensively ...... aging and Alzheimer's disease

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Synaptic genes are extensively ...... aging and Alzheimer's disease

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J.NEUROBIOLAGING.2012.11.024

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Neurobiology of Aging

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Synaptic genes are extensively ...... aging and Alzheimer's disease

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P2093

Carl W Cotman

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Daniel L Gillen

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David H Cribbs

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Joseph Rogers

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Nicole C Berchtold

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Paul D Coleman

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P2860

Neuroligins and neurexins link synaptic function to cognitive disease

Membrane fusion: grappling with SNARE and SM proteins

Neuropathological stageing of Alzheimer-related changes

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

Ephrin regulation of synapse formation, function and plasticity

SNAREs--engines for membrane fusion

Spatio-temporal transcriptome of the human brain

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

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1653-1661

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scholarly article

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10.1016/J.NEUROBIOLAGING.2012.11.024

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6

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34

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2012-12-27T00:00:00Z

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234010269

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23273601

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Alzheimer's disease

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4022280

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