cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists
about
Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferationAn anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamicsG(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channelsMolecular details of cAMP generation in mammalian cells: a tale of two systemsPhosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical ImplicationsCardiac cAMP: production, hydrolysis, modulation and detectionCaV1.2 signaling complexes in the heartPersistent cAMP-signals triggered by internalized G-protein-coupled receptorsStructure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heartLocal response of L-type Ca(2+) current to nitric oxide in frog ventricular myocytesSimultaneous measurements of intracellular cAMP and L-type Ca2+ current in single frog ventricular myocytesThe A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brainAssociation of soluble adenylyl cyclase with the V-ATPase in renal epithelial cellsLocalization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulationMembrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulumMechanisms of cyclic AMP compartmentation revealed by computational models.PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells.Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytesCaveolae, ion channels and cardiac arrhythmias.Use of electron microscopy in the detection of adrenergic receptorsG(s) and adenylyl cyclase in transverse tubules of heart: implications for cAMP-dependent signaling.A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cellTransfected cyclic nucleotide-gated channels as biosensors.Advances in targeting cyclic nucleotide phosphodiesterasesBeta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis.Conserved expression and functions of PDE4 in rodent and human heart.Regulation and organization of adenylyl cyclases and cAMP.PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblastsCyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Inhibitors of cyclic nucleotide phosphodiesterase PDE3 as adjunct therapy for dilated cardiomyopathy.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationInterventricular differences in β-adrenergic responses in the canine heart: role of phosphodiesterases.Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytesThe human near-term myometrial beta 3-adrenoceptor but not the beta 2-adrenoceptor is resistant to desensitisation after sustained agonist stimulation.Porcine left atrial and sinoatrial 5-HT(4) receptor-induced responses: fading of the response and influence of development.AKAPs: the architectural underpinnings of local cAMP signaling.Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.
P2860
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P2860
cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
cAMP compartmentation is respo ...... ls by beta-adrenergic agonists
@ast
cAMP compartmentation is respo ...... ls by beta-adrenergic agonists
@en
type
label
cAMP compartmentation is respo ...... ls by beta-adrenergic agonists
@ast
cAMP compartmentation is respo ...... ls by beta-adrenergic agonists
@en
prefLabel
cAMP compartmentation is respo ...... ls by beta-adrenergic agonists
@ast
cAMP compartmentation is respo ...... ls by beta-adrenergic agonists
@en
P2860
P356
P1476
cAMP compartmentation is respo ...... ls by beta-adrenergic agonists
@en
P2093
Fischmeister R
Jurevicius J
P2860
P304
P356
10.1073/PNAS.93.1.295
P407
P577
1996-01-01T00:00:00Z