A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription - Test2 - elhamkhani - TriplyDB

A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription

A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription

http://www.wikidata.org/entity/Q33627310

about

Comprehensive molecular characterization of human colon and rectal cancer Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies Wnt signalling in smooth muscle cells and its role in cardiovascular disorders Molecular therapy of colorectal cancer: progress and future directions Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review Wnt/β-catenin signalling in prostate cancer Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers Small molecule probes of cellular pathways and networks.Winning WNT: race to Wnt signaling inhibitors.The developing zebrafish (Danio rerio): a vertebrate model for high-throughput screening of chemical libraries.Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma.SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis.Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation via β-catenin signaling.Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism.Genomic era diagnosis and management of hereditary and sporadic colon cancer.In vitro effects of a small-molecule antagonist of the Tcf/ß-catenin complex on endometrial and endometriotic cells of patients with endometriosis.High-throughput screening for identification of inhibitors of EpCAM-dependent growth of hepatocellular carcinoma cells.Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription.The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge.Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine.Emerging drug discovery approaches for selective targeting of "precursor" metastatic breast cancer cells: highlights and perspectives Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.Suppression of GSK-3β activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators.Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13.In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer.Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells.Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.Therapeutic intervention of proanthocyanidins on the migration capacity of melanoma cells is mediated through PGE2 receptors and β-catenin signaling molecules miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity.Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells.Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation.Pharmacological modulation of beta-catenin and its applications in cancer therapy

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A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription

http://www.wikidata.org/entity/Q33627310

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

A useful approach to identify ...... of Wnt-dependent transcription

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A useful approach to identify ...... of Wnt-dependent transcription

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type

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A useful approach to identify ...... of Wnt-dependent transcription

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A useful approach to identify ...... of Wnt-dependent transcription

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A useful approach to identify ...... of Wnt-dependent transcription

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Cancer Research

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A useful approach to identify ...... of Wnt-dependent transcription

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Bozena Pajak

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Branko Latinkic

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P2860

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Early activation of FGF and nodal pathways mediates cardiac specification independently of Wnt/beta-catenin signaling

Wnt/beta-catenin signaling in development and disease

Embryonic stem cell lines derived from human blastocysts

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

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5963-5973

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20610623

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2912498

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