Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
about
Wnt signaling pathways in urological cancers: past decades and still growingR-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5Tankyrase-1 assembly to large protein complexes blocks its telomeric functionThe ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signalingBone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator functionLoss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubismRNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signallingCell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivationZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerDisruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human CellsMethylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signalingRegulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10Tankyrase 1 regulates centrosome function by controlling CPAP stabilityWnt/beta-catenin signaling and small molecule inhibitorsAn intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acidTargeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signalingPromising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt SignalingFunctions of PARylation in DNA Damage Repair PathwaysTargeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatmentReaders of poly(ADP-ribose): designed to be fit for purposeDevelopment of anticancer agents targeting the Wnt/β-catenin signalingChemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative MedicineRegulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin LigasesTargeting the Wnt pathways for therapiesFlavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapiesWnt signaling pathway in non-small cell lung cancerToggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexesWnt signalling in smooth muscle cells and its role in cardiovascular disordersOsteoarthritis pathogenesis: a review of molecular mechanismsTargeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28Targeted therapy for hepatocellular carcinoma: novel agents on the horizonMolecular therapy of colorectal cancer: progress and future directionsCancer stem cells in colorectal cancer from pathogenesis to therapy: controversies and perspectivesTherapeutic targeting of replicative immortalityWnt4 coordinates directional cell migration and extension of the Müllerian duct essential for ontogenesis of the female reproductive tract.Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish
P2860
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P248
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P2860
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@ast
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@en
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@en-gb
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@nl
type
label
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@ast
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@en
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@en-gb
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@nl
prefLabel
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@ast
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@en
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@en-gb
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@nl
P2093
P921
P3181
P356
P1433
P1476
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
@en
P2093
Aleem Fazal
Andreas Bauer
Atwood Cheung
Christina Rau
Christopher J Wilson
Craig Mickanin
Daniel Curtis
Elizabeth Wiellette
Fabrizio Serluca
P2888
P304
P3181
P356
10.1038/NATURE08356
P407
P577
2009-10-01T00:00:00Z
P6179
1018211800