Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. - Test2 - elhamkhani - TriplyDB

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.

http://www.wikidata.org/entity/Q33640240

about

From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics Induction of synaptic long-term potentiation after opioid withdrawal Descending facilitation maintains long-term spontaneous neuropathic pain Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats The puerperium alters spinal cord plasticity following peripheral nerve injury.Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5 Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.Exogenous and endogenous opioid-induced pain hypersensitivity in different rat strains.NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice.Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids.Long-term potentiation in spinal nociceptive pathways as a novel target for pain therapy.5-hydroxytryptamine type 3 receptor modulates opioid-induced hyperalgesia and tolerance in mice.Neural correlates of an injury-free model of central sensitization induced by opioid withdrawal in humans.Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord.Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity.Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat.Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.Continuous opioid therapy (COT) is rarely advisable for refractory chronic daily headache: limited efficacy, risks, and proposed guidelines.Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.Preclinical and early clinical investigations related to monoaminergic pain modulation.Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite.Roles of reactive oxygen and nitrogen species in pain Opioid-induced hyperalgesia and burn pain.Calcium-permeable ion channels in pain signaling.Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain.Parabrachial complex links pain transmission to descending pain modulation.The Effect of Ondansetron on Acute Opioid Tolerance in Patients Receiving Intrathecal Opioids Prior to Cesarean Delivery.Preprotachykinin-A gene disruption attenuates nociceptive sensitivity after opioid administration and incision by peripheral and spinal mechanisms in mice.GluN2B N-methyl-D-aspartate receptor and excitatory amino acid transporter 3 are upregulated in primary sensory neurons after 7 days of morphine administration in rats: implication for opiate-induced hyperalgesia.Epigenetic regulation of spinal cord gene expression contributes to enhanced postoperative pain and analgesic tolerance subsequent to continuous opioid exposure.Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: a randomized, parallel-group, factorial study.Effects of surgery and/or remifentanil administration on the expression of pERK1/2, c-Fos and dynorphin in the dorsal root ganglia in mice.Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla.

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P2860

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.

http://www.wikidata.org/entity/Q33640240

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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En-Tan Zhang

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Josephine Lai

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Louis P Vera-Portocarrero

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Michael H Ossipov

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Todd W Vanderah

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P2860

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process

Opioid-induced hyperalgesia: a qualitative systematic review

Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine

Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

Quantitative assessment of tactile allodynia in the rat paw

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.

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