In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors - Test2 - elhamkhani - TriplyDB

In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors

In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors

http://www.wikidata.org/entity/Q33648377

about

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles Mesofluidic devices for DNA-programmed combinatorial chemistry A sequential strand-displacement strategy enables efficient six-step DNA-templated synthesis.Small-molecule discovery from DNA-encoded chemical libraries.20 years of DNA-encoded chemical libraries.In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors.Highly parallel translation of DNA sequences into small molecules.Active/inactive dual-probe system for selective photoaffinity labeling of small molecule-binding proteins.Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology.Direct comparison of linear and macrocyclic compound libraries as a source of protein ligands A DNA-templated synthesis of encoded small molecules by DNA self-assembly.Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags.Tethered ribozyme ligation enables detection of molecular proximity in homogeneous solutions.Methods for the creation of cyclic Peptide libraries for use in lead discovery.Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library.Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins.DNA-Encoded Dynamic Combinatorial Chemical Libraries.Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming.Automated screening for small organic ligands using DNA-encoded chemical libraries.Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View.Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections.Oligonucleotide-Based Systems for Input-Controlled and Non-Covalently Regulated Protein-Binding DNA-guided display of proteins and protein ligands for the interrogation of biology.Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates.DNA as a molecular ruler: interrogation of a tandem SH2 domain with self-assembled, bivalent DNA-peptide complexes.MacroEvoLution: A New Method for the Rapid Generation of Novel Scaffold-Diverse Macrocyclic Libraries Design, preparation, and selection of DNA-encoded dynamic libraries Modeling Scalable Pattern Generation in DNA Reaction Networks Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization.The Evolution of DNA-Templated Synthesis as a Tool for Materials Discovery.DNA-Encoded Chemical Libraries: A Selection System Based On Endowing Organic Compounds with Amplifiable Information.Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets.Site Covalent Modification of Methionyl Peptides for the Production of FRET Complexes.DNA-encoded chemical libraries: Achievements and remaining challenges.Peptidomimetic bond formation by DNA-templated acyl transfer.Detection of bond formations by DNA-programmed chemical reactions and PCR amplification.The real-time PCR for sensitive protein detection by target-induced intermolecular hybridization.

P2860

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P2860

In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors

http://www.wikidata.org/entity/Q33648377

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

In vitro selection of a DNA-te ...... macrocyclic kinase inhibitors

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In vitro selection of a DNA-te ...... macrocyclic kinase inhibitors

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type

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In vitro selection of a DNA-te ...... macrocyclic kinase inhibitors

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In vitro selection of a DNA-te ...... macrocyclic kinase inhibitors

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In vitro selection of a DNA-te ...... macrocyclic kinase inhibitors

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In vitro selection of a DNA-te ...... macrocyclic kinase inhibitors

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Journal of the American Chemical Society

P1476

In vitro selection of a DNA-te ...... macrocyclic kinase inhibitors

@en

P2093

Christoph E Dumelin

http://www.w3.org/2001/XMLSchema#string

David R Liu

http://www.w3.org/2001/XMLSchema#string

Gerald C Tiu

http://www.w3.org/2001/XMLSchema#string

Kaori Sakurai

http://www.w3.org/2001/XMLSchema#string

Ralph E Kleiner

http://www.w3.org/2001/XMLSchema#string

P2860

Advanced sequencing technologies and their wider impact in microbiology

Accurate whole human genome sequencing using reversible terminator chemistry

The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules

DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes

Reaction discovery enabled by DNA-templated synthesis and in vitro selection

DNA-templated organic synthesis and selection of a library of macrocycles

Crystal structure of aurora-2, an oncogenic serine/threonine kinase

Discovery of selective aminothiazole aurora kinase inhibitors

Design, synthesis and selection of DNA-encoded small-molecule libraries

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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11779-11791

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10.1021/JA104903X

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33

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132

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2010-08-01T00:00:00Z

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45493080

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20681606

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2924185

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