In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83).
about
Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcriptionSystemic priming-boosting immunization with a trivalent plasmid DNA and inactivated murine cytomegalovirus (MCMV) vaccine provides long-term protection against viral replication following systemic or mucosal MCMV challengeThe putative natural killer decoy early gene m04 (gp34) of murine cytomegalovirus encodes an antigenic peptide recognized by protective antiviral CD8 T cells.Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65)Construction and characterization of murine cytomegaloviruses that contain transposon insertions at open reading frames m09 and M83.Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62L(lo) memory-effector cell pool during latent murine cytomegalovirus infection of the lungsComparison of multiple DNA vaccines for protection against cytomegalovirus infection in BALB/c mice.Murine cytomegalovirus open reading frame M27 plays an important role in growth and virulence in mice.Experimental preemptive immunotherapy of murine cytomegalovirus disease with CD8 T-cell lines specific for ppM83 and pM84, the two homologs of human cytomegalovirus tegument protein ppUL83 (pp65).Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotype.Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replicationRecombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties.Strong CD8 T-cell responses following coimmunization with plasmids expressing the dominant pp89 and subdominant M84 antigens of murine cytomegalovirus correlate with long-term protection against subsequent viral challengeSpecific chromosome 1 breaks induced by human cytomegalovirus.Murine cytomegalovirus with a transposon insertional mutation at open reading frame M35 is defective in growth in vivo.DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge.Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells.Targeted deletion of regions rich in immune-evasive genes from the cytomegalovirus genome as a novel vaccine strategy.Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription.Properties of virion transactivator proteins encoded by primate cytomegalovirusesMultiple epitopes in the murine cytomegalovirus early gene product M84 are efficiently presented in infected primary macrophages and contribute to strong CD8+-T-lymphocyte responses and protection following DNA immunization.Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response.Cytomegalovirus pp65 limits dissemination but is dispensable for persistence.Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV.Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replicationMolecular, biological, and in vivo characterization of the guinea pig cytomegalovirus (CMV) homologs of the human CMV matrix proteins pp71 (UL82) and pp65 (UL83).New genes from old: redeployment of dUTPase by herpesviruses.Feeling manipulated: cytomegalovirus immune manipulation.Human cytomegalovirus pp65 lower matrix protein: a humoral immunogen for systemic lupus erythematosus patients and autoantibody accelerator for NZB/W F1 mice.Peripheral blood lymphocyte responses to cytomegalovirus seropositivity after allogeneic-hematopoietic stem cell transplantation
P2860
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P2860
In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83).
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
In vivo replication, latency, ...... n cytomegalovirus pp65 (UL83).
@ast
In vivo replication, latency, ...... n cytomegalovirus pp65 (UL83).
@en
type
label
In vivo replication, latency, ...... n cytomegalovirus pp65 (UL83).
@ast
In vivo replication, latency, ...... n cytomegalovirus pp65 (UL83).
@en
prefLabel
In vivo replication, latency, ...... n cytomegalovirus pp65 (UL83).
@ast
In vivo replication, latency, ...... n cytomegalovirus pp65 (UL83).
@en
P2093
P2860
P1433
P1476
In vivo replication, latency, ...... an cytomegalovirus pp65 (UL83)
@en
P2093
C S Morello
D H Spector
L D Cranmer
P2860
P304
P577
1999-09-01T00:00:00Z