Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
about
Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicingPurification and characterization of native spliceosomes suitable for three-dimensional structural analysis.U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reactionA novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reactionThe mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosomeA T to G mutation in the polypyrimidine tract of the second intron of the human beta-globin gene reduces in vitro splicing efficiency: evidence for an increased hnRNP C interactionPre-mRNA splicing within an assembled yeast spliceosome requires an RNA-dependent ATPase and ATP hydrolysisSpecific cleavage of hyper-edited dsRNAsProtein composition of mammalian spliceosomes assembled in vitroA ribonuclease specific for inosine-containing RNA: a potential role in antiviral defence?Identification of a human protein that recognizes the 3' splice site during the second step of pre-mRNA splicing.Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB).The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomes.Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa proteinFunctional association of the Microprocessor complex with the spliceosome.The polypyrimidine tract binding protein (PTB) represses splicing of exon 6B from the beta-tropomyosin pre-mRNA by directly interfering with the binding of the U2AF65 subunitLocalization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin specklesSmooth muscle alternative splicing induced in fibroblasts by heterologous expression of a regulatory geneNormal and abnormal mechanisms of gene splicing and relevance to inherited skin diseasesAutonomous splicing and complementation of in vivo-assembled spliceosomesAccumulation of a novel spliceosomal complex on pre-mRNAs containing branch site mutations.A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract.SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complexScanning and competition between AGs are involved in 3' splice site selection in mammalian intronscis-acting sequences involved in exon selection in the chicken beta-tropomyosin geneDifferential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitroInteractions between the terminal bases of mammalian introns are retained in inosine-containing pre-mRNAs.Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon.The U1 small nuclear ribonucleoprotein/5' splice site interaction affects U2AF65 binding to the downstream 3' splice site.Detection of a novel ATP-dependent cross-linked protein at the 5' splice site-U1 small nuclear RNA duplex by methylene blue-mediated photo-cross-linking.Characterization of an RNP complex that assembles on the Rous sarcoma virus negative regulator of splicing element.Isolation and accumulation of spliceosomal assembly intermediates.Alterations of RNase H sensitivity of the 3' splice site region during the in vitro splicing reaction.Splicing factor SF4 is dispensable for the assembly of a functional splicing complex and participates in the subsequent steps of the splicing reaction.Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon.hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B.RS domain-splicing signal interactions in splicing of U12-type and U2-type introns.Metal ion catalysis during splicing of premessenger RNA
P2860
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P2860
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
description
1988 nî lūn-bûn
@nan
1988 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
@ast
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
@en
type
label
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
@ast
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
@en
prefLabel
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
@ast
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
@en
P2093
P2860
P356
P1476
Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
@en
P2093
P2860
P304
P356
10.1073/PNAS.85.19.7216
P407
P577
1988-10-01T00:00:00Z