Hsp40 chaperones promote degradation of the HERG potassium channel.
about
Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1RING finger protein RNF207, a novel regulator of cardiac excitationTranslational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspectsThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyMolecular pathogenesis of long QT syndrome type 2Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutationEmerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking.Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activityFKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulumMechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis.Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput ScreeningMechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.Sequence and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency.Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia.Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.Identification of GABA(C) receptor protein homeostasis network components from three tandem mass spectrometry proteomics approaches.Transcriptional Network Architecture of Breast Cancer Molecular SubtypesThe role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channelshERG quality control and the long QT syndrome.Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.Molecular Pathophysiology of Congenital Long QT Syndrome.Cysteine string protein limits expression of the large conductance, calcium-activated K⁺ (BK) channel.CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity.Hsp70/J-protein machinery from Glossina morsitans morsitans, vector of African trypanosomiasisMiR-17-5p impairs trafficking of H-ERG K+ channel protein by targeting multiple er stress-related chaperones during chronic oxidative stressThe DNAJA2 substrate release mechanism is essential for chaperone-mediated folding.The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein.Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels.Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2.
P2860
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P2860
Hsp40 chaperones promote degradation of the HERG potassium channel.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Hsp40 chaperones promote degradation of the HERG potassium channel.
@ast
Hsp40 chaperones promote degradation of the HERG potassium channel.
@en
type
label
Hsp40 chaperones promote degradation of the HERG potassium channel.
@ast
Hsp40 chaperones promote degradation of the HERG potassium channel.
@en
prefLabel
Hsp40 chaperones promote degradation of the HERG potassium channel.
@ast
Hsp40 chaperones promote degradation of the HERG potassium channel.
@en
P2093
P2860
P356
P1476
Hsp40 chaperones promote degradation of the HERG potassium channel.
@en
P2093
Alvin Shrier
Christine Hantouche
Jason C Young
Michael J H Wong
Roxana Atanasiu
Valerie E Walker
P2860
P304
P356
10.1074/JBC.M109.024000
P407
P577
2009-11-25T00:00:00Z