Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy - Test2 - elhamkhani - TriplyDB

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

http://www.wikidata.org/entity/Q33670282

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Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose Genetically engineered mouse models of Parkinson's disease Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease Autophagy and neurodegeneration Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders Protein degradation pathways in Parkinson's disease: curse or blessing Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders Genetic and chemical activation of TFEB mediates clearance of aggregated α-synuclein Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy Regulation of amyloid precursor protein processing by the Beclin 1 complex Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model.Stem cell models of Alzheimer's disease: progress and challenges.Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.HIV life cycle, innate immunity and autophagy in the central nervous system p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions Macroautophagy abnormality in essential tremor.Taking aim at Alzheimer's disease through the mammalian target of rapamycin Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.The many faces of α-synuclein: from structure and toxicity to therapeutic target.Autophagy failure in Alzheimer's disease--locating the primary defect.Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.NURR1 in Parkinson disease--from pathogenesis to therapeutic potential.HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders.Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

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Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

http://www.wikidata.org/entity/Q33670282

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Selective molecular alteration ...... odels of alpha-synucleinopathy

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Selective molecular alteration ...... odels of alpha-synucleinopathy

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Selective molecular alteration ...... odels of alpha-synucleinopathy

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Selective molecular alteration ...... odels of alpha-synucleinopathy

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Selective molecular alteration ...... odels of alpha-synucleinopathy

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Selective molecular alteration ...... odels of alpha-synucleinopathy

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Selective molecular alteration ...... odels of alpha-synucleinopathy

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Amy Paulino

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Anthony Adame

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Douglas Galasko

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P2860

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

Organization of the pre-autophagosomal structure responsible for autophagosome formation

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Neuropathological stageing of Alzheimer-related changes

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Alpha-synuclein-positive structures induced in leupeptin-infused rats

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