MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.
about
Novel strategies to target the ubiquitin proteasome system in multiple myelomaInactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma.Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathwayCase-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen.Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors.The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells.SCF ubiquitin ligase-targeted therapies.Role of the ubiquitin proteasome system in hematologic malignancies.Carvedilol-responsive microRNAs, miR-199a-3p and -214 protect cardiomyocytes from simulated ischemia-reperfusion injury.MLN4924, a First-in-Class NEDD8-Activating Enzyme Inhibitor, Attenuates IFN-β Production.Cyclophilin A as a downstream effector of PI3K/Akt signalling pathway in multiple myeloma cells.NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma.Targeting neddylation effectively antagonizes nuclear factor-κB in chronic lymphocytic leukemia B-cells.The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors.Synaptic structure and function are altered by the neddylation inhibitor MLN4924.Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing14-3-3ζ binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors.Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62.Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer.MLN4924 neddylation inhibitor promotes cell death in paclitaxel-resistant human lung adenocarcinoma cells.Protein neddylation and its alterations in human cancers for targeted therapy.Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance.Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons.Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.
P2860
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P2860
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.
description
2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
MLN4924, an NAE inhibitor, sup ...... REDD1 in human myeloma cells.
@ast
MLN4924, an NAE inhibitor, sup ...... REDD1 in human myeloma cells.
@en
type
label
MLN4924, an NAE inhibitor, sup ...... REDD1 in human myeloma cells.
@ast
MLN4924, an NAE inhibitor, sup ...... REDD1 in human myeloma cells.
@en
prefLabel
MLN4924, an NAE inhibitor, sup ...... REDD1 in human myeloma cells.
@ast
MLN4924, an NAE inhibitor, sup ...... REDD1 in human myeloma cells.
@en
P2093
P2860
P1433
P1476
MLN4924, an NAE inhibitor, sup ...... REDD1 in human myeloma cells.
@en
P2093
Claire Torre
Jonathan L Kaufman
Lawrence H Boise
Leon Bernal
R Donald Harvey
Shannon M Matulis
Shi-Yong Sun
P2860
P304
P356
10.1182/BLOOD-2013-08-521914
P407
P50
P577
2014-04-08T00:00:00Z