Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures.
about
Moving towards effective therapeutic strategies for Neuronal Ceroid LipofuscinosisAlternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagementInhibition of microglia activation as a phenotypic assay in early drug discoveryImine reductases: a comparison of glutamate dehydrogenase to ketimine reductases in the brainA cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologiesALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the diseaseCollapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, and conformational flexibility.Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines.Chemistry-based functional proteomics for drug target deconvolution.Progress in therapy development for amyotrophic lateral sclerosisIdentification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation.Redox regulation of autophagy in healthy brain and neurodegeneration.A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease.Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.A derivative of the CRMP2 binding compound lanthionine ketimine provides neuroprotection in a mouse model of cerebral ischemia.Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein TauCollapsin response mediator protein-2: an emerging pathologic feature and therapeutic target for neurodisease indications.Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools.Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain.Lysine metabolism in mammalian brain: an update on the importance of recent discoveries.Chemical proteomic strategies for the discovery and development of anticancer drugs.Microtubule and microtubule associated protein anomalies in psychiatric disease.CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury.Reciprocal Control of Thyroid Binding and the Pipecolate Pathway in the Brain.The Sulfur Metabolite Lanthionine: Evidence for a Role as a Novel Uremic Toxin.Affinity-based target deconvolution of safranal.Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis.Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function.Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters.Lanthionine ketimine ethyl ester partially rescues neurodevelopmental defects in unc-33 (DPYSL2/CRMP2) mutants.Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.Lanthionine ketimine-5-ethyl ester provides neuroprotection in a zebrafish model of okadaic acid-induced Alzheimer's disease.Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging.
P2860
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P2860
Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Proteomic identification of bi ...... and motoneuron cell cultures.
@ast
Proteomic identification of bi ...... and motoneuron cell cultures.
@en
type
label
Proteomic identification of bi ...... and motoneuron cell cultures.
@ast
Proteomic identification of bi ...... and motoneuron cell cultures.
@en
prefLabel
Proteomic identification of bi ...... and motoneuron cell cultures.
@ast
Proteomic identification of bi ...... and motoneuron cell cultures.
@en
P2093
P2860
P1476
Proteomic identification of bi ...... and motoneuron cell cultures.
@en
P2093
Alexandar Christov
Kenneth Hensley
Kenneth W Jackson
Shekhar Kamat
Stephen Snow
X Cai Zhang
P2860
P304
P356
10.1523/JNEUROSCI.5247-09.2010
P407
P577
2010-02-01T00:00:00Z