Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
about
Role of Ikaros in T-cell acute lymphoblastic leukemiaJdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosityA cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemiaDeletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Preclinical efficacy of MEK inhibition in Nras-mutant AML.Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant miceInhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic NrasTargeting oncogenic Ras signaling in hematologic malignancies.Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes.Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivoA mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasisPhenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.RasGRP Ras guanine nucleotide exchange factors in cancer.Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic TargetingTowards an understanding of the biology and targeted treatment of paediatric relapsed acute lymphoblastic leukaemia.KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.Genomic characterization of paediatric acute lymphoblastic leukaemia: an opportunity for precision medicine therapeutics.Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesisTRIB2 regulates normal and stress-induced thymocyte proliferation.Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.Ikaros is a critical target during simultaneous exposure to X-rays and N-ethyl-N-nitrosourea in mouse T-cell lymphomagenesis.Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.Leukemia-specific delivery of mutant NOTCH1 targeted therapy.The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer.Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice.Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.
P2860
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P2860
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Mutant Ikzf1, KrasG12D, and No ...... responses to targeted agents.
@ast
Mutant Ikzf1, KrasG12D, and No ...... responses to targeted agents.
@en
type
label
Mutant Ikzf1, KrasG12D, and No ...... responses to targeted agents.
@ast
Mutant Ikzf1, KrasG12D, and No ...... responses to targeted agents.
@en
prefLabel
Mutant Ikzf1, KrasG12D, and No ...... responses to targeted agents.
@ast
Mutant Ikzf1, KrasG12D, and No ...... responses to targeted agents.
@en
P2093
P2860
P356
P1476
Mutant Ikzf1, KrasG12D, and No ...... responses to targeted agents.
@en
P2093
Andrew McDaniel
Benjamin S Braun
Hio Chung Kang
Jason Wong
Keiko Akagi
Kevan Shokat
Kevin Shannon
Linda Wolff
Monique Dail
P2860
P304
P356
10.1073/PNAS.1001064107
P407
P577
2010-03-01T00:00:00Z