The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.
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Biophysical characterization of α-synuclein and its controversial structureGenetically engineered mouse models of Parkinson's diseaseHuman A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neuronsMore than a Rumor Spreads in Parkinson's DiseaseAlpha-synuclein spreading in Parkinson's diseaseEnergy failure: does it contribute to neurodegeneration?Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-MitoxyNeuron-selective changes in RNA transcripts related to energy metabolism in toxic models of parkinsonism in rodents.Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss.α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicityThe regulation of catalase activity by PPAR γ is affected by α-synuclein.Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synucleinAlpha-synuclein function and dysfunction on cellular membranes.Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease.Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's diseaseΑ-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease.Mitochondrial dysfunction in genetic animal models of Parkinson's diseaseParkinson's disease and α-synuclein expressionUnderstanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutationα-Synuclein and mitochondria: partners in crime?α-Synuclein in Parkinson's disease.Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson's Disease?Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.Integrating pathways of Parkinson's disease in a molecular interaction map.Iron in neurodegenerative disorders of protein misfolding: a case of prion disorders and Parkinson's disease.The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Cell Biology and Pathophysiology of α-Synuclein.α-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions.Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo.Tetrahydroxystilbene glucoside inhibits α-synuclein aggregation and apoptosis in A53T α-synuclein-transfected cells exposed to MPP.
P2860
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P2860
The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The transgenic overexpression ...... tes with complex I inhibition.
@ast
The transgenic overexpression ...... tes with complex I inhibition.
@en
type
label
The transgenic overexpression ...... tes with complex I inhibition.
@ast
The transgenic overexpression ...... tes with complex I inhibition.
@en
prefLabel
The transgenic overexpression ...... tes with complex I inhibition.
@ast
The transgenic overexpression ...... tes with complex I inhibition.
@en
P2093
P2860
P921
P356
P1476
The transgenic overexpression ...... ates with complex I inhibition
@en
P2093
Eugenia Yakunin
Ronit Sharon
Virginie Loeb
P2860
P304
P356
10.1074/JBC.M109.061051
P407
P50
P577
2010-01-06T00:00:00Z