Sodium channel selectivity filter regulates antiarrhythmic drug binding
about
The pharmacology of cyclic nucleotide-gated channels: emerging from the darknessThe hitchhiker's guide to the voltage-gated sodium channel galaxyIon selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channelsMechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channelsMexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channelLocating the route of entry and binding sites of benzocaine and phenytoin in a bacterial voltage gated sodium channelA Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECGExploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Energetic localization of saxitoxin in its channel binding site.Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibuleBatrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibuleA revised view of cardiac sodium channel "blockade" in the long-QT syndromeVerapamil block of T-type calcium channels.Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.Cyclic nucleotide-gated channel block by hydrolysis-resistant tetracaine derivativesDocking of mu-conotoxin GIIIA in the sodium channel outer vestibule.Compound heterozygous mutations P336L and I1660V in the human cardiac sodium channel associated with the Brugada syndrome.Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence.Permeation of large tetra-alkylammonium cations through mutant and wild-type voltage-gated sodium channels as revealed by relief of block at high voltageBlock of cyclic nucleotide-gated channels by tetracaine derivatives: role of apolar interactions at two distinct locationsModifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficaciesTrans-channel interactions in batrachotoxin-modified rat skeletal muscle sodium channels: kinetic analysis of mutual inhibition between mu-conotoxin GIIIA derivatives and amine blockersLidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel.Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.Halogen substituents on the aromatic moiety of the tetracaine scaffold improve potency of cyclic nucleotide-gated channel block.The sodium channel as a target for local anesthetic drugs.Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels.State-Dependent Inhibition of Sodium Channels by Local Anesthetics: A 40-Year Evolution.The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel.Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATXMechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants.Sodium channels: ionic model of slow inactivation and state-dependent drug binding.Increased sensitivity to local anesthetic drugs: bedside to bench.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.
P2860
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P2860
Sodium channel selectivity filter regulates antiarrhythmic drug binding
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Sodium channel selectivity filter regulates antiarrhythmic drug binding
@ast
Sodium channel selectivity filter regulates antiarrhythmic drug binding
@en
type
label
Sodium channel selectivity filter regulates antiarrhythmic drug binding
@ast
Sodium channel selectivity filter regulates antiarrhythmic drug binding
@en
prefLabel
Sodium channel selectivity filter regulates antiarrhythmic drug binding
@ast
Sodium channel selectivity filter regulates antiarrhythmic drug binding
@en
P2093
P2860
P356
P1476
Sodium channel selectivity filter regulates antiarrhythmic drug binding
@en
P2093
P2860
P304
14126-14131
P356
10.1073/PNAS.94.25.14126
P407
P577
1997-12-01T00:00:00Z