A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule.
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Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxinStructural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIADesign of Bioactive Peptides from Naturally Occurring -Conotoxin StructuresExpression of skeletal muscle-type voltage-gated Na+ channel in rat and human prostate cancer cell linesExploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Energetic localization of saxitoxin in its channel binding site.Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibuleFolding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatusSodium channel selectivity filter regulates antiarrhythmic drug bindingTopology of the P segments in the sodium channel pore revealed by cysteine mutagenesisPore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.Molecular dynamics study of binding of µ-conotoxin GIIIA to the voltage-gated sodium channel Na(v)1.4.Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site.Tonic and phasic tetrodotoxin block of sodium channels with point mutations in the outer pore regionNovel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.Structure and function of voltage-gated sodium channels.A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule.Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system.Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sievingmu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.Molecular architecture of the voltage-dependent Na channel: functional evidence for alpha helices in the pore.Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin.Charged surface area of maurocalcine determines its interaction with the skeletal ryanodine receptor.Trans-channel interactions in batrachotoxin-modified rat skeletal muscle sodium channels: kinetic analysis of mutual inhibition between mu-conotoxin GIIIA derivatives and amine blockersThe outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.Determinants of inhibition of transiently expressed voltage-gated calcium channels by omega-conotoxins GVIA and MVIIA.Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.Functional and structural features of gamma-zeathionins, a new class of sodium channel blockers.Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIICConotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel.Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore.Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block.Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels.Dependence of mu-conotoxin block of sodium channels on ionic strength but not on the permeating [Na+]: implications for the distinctive mechanistic interactions between Na+ and K+ channel pore-blocking toxins and their molecular targets.Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity.
P2860
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P2860
A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule.
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@ast
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@en
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@nl
type
label
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@ast
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@en
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@nl
prefLabel
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@ast
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@en
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@nl
P2093
P2860
P1433
P1476
A mu-conotoxin-insensitive Na+ ...... g site at the outer vestibule.
@en
P2093
P2860
P304
P356
10.1016/S0006-3495(95)80045-7
P407
P577
1995-11-01T00:00:00Z