Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.
about
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseSCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) proteinDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerDifferent Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress ResponsePlk1- and beta-TrCP-dependent degradation of Bora controls mitotic progressionPhosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1Ubiquitin and SUMO systems in the regulation of mitotic checkpointsEastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir.The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu functionMiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A.Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor.Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligaseUnscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage.Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domainCasein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation.Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonismThe NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.Interaction and co-localization of JC virus large T antigen and the F-box protein β-transducin-repeat containing protein.The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protectionNovel insights into the molecular mechanisms governing Mdm2 ubiquitination and destructionDNA Damage Regulates Translation through β-TRCP Targeting of CRePDeubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.SCF ubiquitin ligases in the maintenance of genome stability.Mechanism of degradation of CPEB during Xenopus oocyte maturation.Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteinsCDC25 phosphatases in cancer cells: key players? Good targets?The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest.Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.The multiple layers of ubiquitin-dependent cell cycle control.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.Cif type III effector protein: a smart hijacker of the host cell cycle.Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair.NF-κB and the link between inflammation and cancer.Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation.
P2860
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P2860
Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Beta-TrCP recognizes a previou ...... dc25A and Cdc25B phosphatases.
@ast
Beta-TrCP recognizes a previou ...... dc25A and Cdc25B phosphatases.
@en
type
label
Beta-TrCP recognizes a previou ...... dc25A and Cdc25B phosphatases.
@ast
Beta-TrCP recognizes a previou ...... dc25A and Cdc25B phosphatases.
@en
prefLabel
Beta-TrCP recognizes a previou ...... dc25A and Cdc25B phosphatases.
@ast
Beta-TrCP recognizes a previou ...... dc25A and Cdc25B phosphatases.
@en
P2093
P2860
P356
P1476
Beta-TrCP recognizes a previou ...... dc25A and Cdc25B phosphatases.
@en
P2093
Katsuhiro Uto
Noriyuki Sagata
Yoshinori Kanemori
P2860
P304
P356
10.1073/PNAS.0501873102
P407
P577
2005-04-21T00:00:00Z