Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response - Test2 - elhamkhani - TriplyDB

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

http://www.wikidata.org/entity/Q27647812

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Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Role of Nrf2 in oxidative stress and toxicity Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance Pharmacology and Clinical Drug Candidates in Redox Medicine Effect of redox modulating NRF2 activators on chronic kidney disease Mechanisms of drug-induced liver injury Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes Structural analysis of the complex of Keap1 with a prothymosin α peptide Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1 The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria Stress-activated cap'n'collar transcription factors in aging and human disease CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism p62 links autophagy and Nrf2 signaling The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response.The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases.Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells.Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

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Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

http://www.wikidata.org/entity/Q27647812

description

2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

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2007年論文

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2007年論文

@zh-hant

2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Different Electrostatic Potent ...... h in Oxidative Stress Response

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Different Electrostatic Potent ...... h in Oxidative Stress Response

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Different Electrostatic Potent ...... h in Oxidative Stress Response

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Different Electrostatic Potent ...... h in Oxidative Stress Response

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Different Electrostatic Potent ...... h in Oxidative Stress Response

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Different Electrostatic Potent ...... h in Oxidative Stress Response

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Different Electrostatic Potent ...... h in Oxidative Stress Response

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Different Electrostatic Potent ...... h in Oxidative Stress Response

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Molecular and Cellular Biology

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Different Electrostatic Potent ...... h in Oxidative Stress Response

@en

P2093

Balasundaram Padmanabhan

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Chengwei Shang

http://www.w3.org/2001/XMLSchema#string

Kit I Tong

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Yosuke Hirotsu

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

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7511-21

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scholarly article

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1105632

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10.1128/MCB.00753-07

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21

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27

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Shigeyuki Yokoyama

Akira Kobayashi

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2007-11-01T00:00:00Z

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17785452

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2169061

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