A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
about
MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityUnbalanced replication as a major source of genetic instability in cancer cellsFunctional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination.Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroidsMorphogenics as a tool for target discovery and drug development.Human antibodies for immunotherapy development generated via a human B cell hybridoma technology.Mechanisms of inactivation of MLH1 in hereditary nonpolyposis colorectal carcinoma: a novel approach.Evidence for a recessive inheritance of Turcot's syndrome caused by compound heterozygous mutations within the PMS2 gene.Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome.Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer.Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.The "comparative growth assay": examining the interplay of anti-cancer agents with cells carrying single gene alterations.Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoproteinGene expression analysis of tumor spheroids reveals a role for suppressed DNA mismatch repair in multicellular resistance to alkylating agents.The hMSH2(M688R) Lynch syndrome mutation may function as a dominant negative.Microsatellite instability in the peripheral blood leukocytes of HNPCC patients.Extensive molecular screening for hereditary non-polyposis colorectal cancerConstitutive deficiency in DNA mismatch repair.Protein and genome evolution in Mammalian cells for biotechnology applications.Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex.Functional and physical interaction between the mismatch repair and FA-BRCA pathways.NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair.Rapid generation of rice mutants via the dominant negative suppression of the mismatch repair protein OsPMS1.The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair.Contribution of human mlh1 and pms2 ATPase activities to DNA mismatch repair.Mutation frequency in coding and non-coding repeat sequences in mismatch repair deficient cells derived from normal human tissue.Identification of new tumor suppressor genes based on in vivo functional inactivation of a candidate gene.Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system.Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours.Yeast mutator phenotype enforced by Arabidopsis PMS1 expression.Low-level microsatellite instability phenotype in sporadic glioblastoma multiforme.An Organismal CNV Mutator Phenotype Restricted to Early Human Development.Low level of microsatellite instability in paediatric malignant astrocytomas.
P2860
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P2860
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
@ast
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
@en
type
label
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
@ast
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
@en
prefLabel
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
@ast
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
@en
P2093
P2860
P356
P1476
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
@en
P2093
N C Nicolaides
S J Littman
P2860
P304
P356
10.1128/MCB.18.3.1635
P407
P577
1998-03-01T00:00:00Z