Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity - Test2 - elhamkhani - TriplyDB

Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity

Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity

http://www.wikidata.org/entity/Q33788724

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Human metapneumovirus M2-2 protein inhibits innate cellular signaling by targeting MAVS Human Metapneumovirus: lessons learned over the first decade Recent vaccine development for human metapneumovirus Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus Structure and Self-Assembly of the Calcium Binding Matrix Protein of Human Metapneumovirus Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo.Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates Chimeric recombinant human metapneumoviruses with the nucleoprotein or phosphoprotein open reading frame replaced by that of avian metapneumovirus exhibit improved growth in vitro and attenuation in vivo Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase The characterization of monoclonal antibodies to human metapneumovirus and the detection of multiple forms of the virus nucleoprotein and phosphoprotein.Rescue of recombinant Marburg virus from cDNA is dependent on nucleocapsid protein VP30 Small hydrophobic protein of human metapneumovirus does not affect virus replication and host gene expression in vitro Small Animal Models for Human Metapneumovirus: Cotton Rat is More Permissive than Hamster and Mouse.Recovery of avian metapneumovirus subgroup C from cDNA: cross-recognition of avian and human metapneumovirus support proteins.Modification of the trypsin-dependent cleavage activation site of the human metapneumovirus fusion protein to be trypsin independent does not increase replication or spread in rodents or nonhuman primates.Nonsegmented negative-strand viruses as vaccine vectors.Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo.Frequent frameshift and point mutations in the SH gene of human metapneumovirus passaged in vitro.Genomic analysis of four human metapneumovirus prototypes Identification of a novel virulence factor in recombinant pneumonia virus of mice.Viral and host factors in human respiratory syncytial virus pathogenesis.Epidemiology of human metapneumovirus.Live vaccines for human metapneumovirus designed by reverse genetics.The marburg virus 3' noncoding region structurally and functionally differs from that of ebola virus.Phosphorylation of Human Metapneumovirus M2-1 Protein Upregulates Viral Replication and Pathogenesis.Human metapneumovirus in the preterm neonate: current perspectives Human metapneumovirus antagonism of innate immune responses.RNA-based viral vectors.New Approaches for Immunization and Therapy against Human Metapneumovirus Modulation of Host Immunity by the Human Metapneumovirus.Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection.Current developments and prospects on human metapneumovirus vaccines.Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters.Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells.Coupled translation of the second open reading frame of M2 mRNA is sequence dependent and differs significantly within the subfamily Pneumovirinae.Deletion of the M2-2 gene from avian metapneumovirus subgroup C impairs virus replication and immunogenicity in Turkeys.Human metapneumovirus - what we know now.

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Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity

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2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2005年の論文

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Deletion of M2 gene open readi ...... ttenuation, and immunogenicity

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Deletion of M2 gene open readi ...... ttenuation, and immunogenicity

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Deletion of M2 gene open readi ...... ttenuation, and immunogenicity

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Deletion of M2 gene open readi ...... ttenuation, and immunogenicity

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Deletion of M2 gene open readi ...... ttenuation, and immunogenicity

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Deletion of M2 gene open readi ...... ttenuation, and immunogenicity

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JVI.79.11.6588-6597.2005

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Journal of Virology

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Deletion of M2 gene open readi ...... ttenuation, and immunogenicity

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Brian R Murphy

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Cindy L Luongo

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Kim C Tran

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Lijuan Yang

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Mario H Skiadopoulos

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Peter L Collins

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Quynh N Pham

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Stéphane Biacchesi

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Ursula J Buchholz

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P2860

The Sendai virus P gene expresses both an essential protein and an inhibitor of RNA synthesis by shuffling modules via mRNA editing

Respiratory syncytial virus M2-1 protein requires phosphorylation for efficient function and binds viral RNA during infection

Transcription elongation factor of respiratory syncytial virus, a nonsegmented negative-strand RNA virus.

Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees

Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systems

Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5' proximal open reading frame of the M2 mRNA in gene expression and provides a capability for va

The product of the respiratory syncytial virus M2 gene ORF1 enhances readthrough of intergenic junctions during viral transcription

Role of the M2-1 transcription antitermination protein of respiratory syncytial virus in sequential transcription.

A newly discovered human pneumovirus isolated from young children with respiratory tract disease.

Requirement of cysteines and length of the human respiratory syncytial virus M2-1 protein for protein function and virus viability

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6588-6597

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scholarly article

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10.1128/JVI.79.11.6588-6597.2005

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11

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79

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2005-06-01T00:00:00Z

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15890897

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1112115

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