Long tract of untranslated CAG repeats is deleterious in transgenic mice - Test2 - elhamkhani - TriplyDB

Long tract of untranslated CAG repeats is deleterious in transgenic mice

Long tract of untranslated CAG repeats is deleterious in transgenic mice

http://www.wikidata.org/entity/Q33808904

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RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Mechanisms of RNA-induced toxicity in CAG repeat disorders RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats C9orf72 nucleotide repeat structures initiate molecular cascades of disease.Oligonucleotide-based strategies to combat polyglutamine diseases.Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts Polyglutamine repeats are associated to specific sequence biases that are conserved among eukaryotes.Diced triplets expose neurons to RISC.An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseases Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathology Molecular, physiological, and motor performance defects in DMSXL mice carrying >1,000 CTG repeats from the human DM1 locus.Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.The role of the immune system in triplet repeat expansion diseases Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target RNA-binding protein misregulation in microsatellite expansion disorders In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats CAG expansion induces nucleolar stress in polyglutamine diseases.Lack of miRNA Misregulation at Early Pathological Stages in Drosophila Neurodegenerative Disease Models.The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches--toward anti-sense therapy against TREDs Neurodegeneration the RNA way RNA toxicity in polyglutamine disorders: concepts, models, and progress of research Exploring cells with targeted biosensors Trojan triplets: RNA-based pathomechanisms for muscle dysfunction in Huntington's disease.Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases CAG repeat RNA as an auxiliary toxic agent in polyglutamine disorders.Cellular toxicity of expanded RNA repeats: focus on RNA foci.Role of noncoding RNAs in trinucleotide repeat neurodegenerative disorders.RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity.Small non-coding RNAs add complexity to the RNA pathogenic mechanisms in trinucleotide repeat expansion diseases.Allele-selective suppression of mutant genes in polyglutamine diseases.RNA toxicity induced by expanded CAG repeats in Huntington's disease.Protein sequestration as a normal function of long noncoding RNAs and a pathogenic mechanism of RNAs containing nucleotide repeat expansions.Role of context in RNA structure: flanking sequences reconfigure CAG motif folding in huntingtin exon 1 transcripts.Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells.Design of Bivalent Nucleic Acid Ligands for Recognition of RNA-Repeated Expansion Associated with Huntington's Disease.

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P2860

Long tract of untranslated CAG repeats is deleterious in transgenic mice

http://www.wikidata.org/entity/Q33808904

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Long tract of untranslated CAG repeats is deleterious in transgenic mice

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Long tract of untranslated CAG repeats is deleterious in transgenic mice

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type

label

Long tract of untranslated CAG repeats is deleterious in transgenic mice

@ast

Long tract of untranslated CAG repeats is deleterious in transgenic mice

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prefLabel

Long tract of untranslated CAG repeats is deleterious in transgenic mice

@ast

Long tract of untranslated CAG repeats is deleterious in transgenic mice

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P1476

Long tract of untranslated CAG repeats is deleterious in transgenic mice

@en

P2093

Chui-Yen Li

http://www.w3.org/2001/XMLSchema#string

Huichin Pan

http://www.w3.org/2001/XMLSchema#string

Kuang-Ming Hsiao

http://www.w3.org/2001/XMLSchema#string

Li-Chun Wang

http://www.w3.org/2001/XMLSchema#string

Luen-Kui Chen

http://www.w3.org/2001/XMLSchema#string

Min-Jon Lin

http://www.w3.org/2001/XMLSchema#string

Ren-Jun Hsu

http://www.w3.org/2001/XMLSchema#string

P2860

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy

The fragile-X premutation: a maturing perspective.

RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9

Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats

Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

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49800654

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21283659

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3025035

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