Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
about
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseGating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallographyRecent advances in Cys-loop receptor structure and functionAromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residuesIn silico models for the human alpha4beta2 nicotinic acetylcholine receptor.Cholesterol enhances surface water diffusion of phospholipid bilayers.Conotoxins targeting nicotinic acetylcholine receptors: an overviewAcetylcholine receptor channels activated by a single agonist molecule.Acetylcholine receptors and myasthenia.Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating.Opening rate of acetylcholine receptor channels.The quality of maximum likelihood estimates of ion channel rate constants.Fast kinetic analysis of ligand-gated ion channels.An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics.Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranesFree-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channelsAn allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Analysis of agonism and inverse agonism in functional assays with constitutive activity: estimation of orthosteric ligand affinity constants for active and inactive receptor statesThe functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis.Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromesState-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit.Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants.Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating.Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules boundInitial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptorMolecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity.Asymmetric transmitter binding sites of fetal muscle acetylcholine receptors shape their synaptic responseNumber and locations of agonist binding sites required to activate homomeric Cys-loop receptorsA mechanism for acetylcholine receptor gating based on structure, coupling, phi, and flip.What single-channel analysis tells us of the activation mechanism of ligand-gated channels: the case of the glycine receptor.Expression of the human glycine receptor alpha 1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor density.The energy and work of a ligand-gated ion channel.Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.Rapid activation, desensitization, and resensitization of synaptic channels of crayfish muscle after glutamate pulses.Neuronal nicotinic receptor subtypes.The role of loop 5 in acetylcholine receptor channel gating.Tyrosine 62 of the gamma-aminobutyric acid type A receptor beta 2 subunit is an important determinant of high affinity agonist binding.Cooperativity in cyclic nucleotide-gated ion channels.
P2860
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P2860
Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
description
1989 nî lūn-bûn
@nan
1989 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
@ast
Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
@en
type
label
Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
@ast
Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
@en
prefLabel
Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
@ast
Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
@en
P2860
P356
P1476
Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.
@en
P2093
Jackson MB
P2860
P304
P356
10.1073/PNAS.86.7.2199
P407
P577
1989-04-01T00:00:00Z