Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.
about
An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites.A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAA receptors.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.Disulphide trapping of the GABA(A) receptor reveals the importance of the coupling interface in the action of benzodiazepines.Partial agonism of taurine at gamma-containing native and recombinant GABAA receptorsDifferent residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding.Use of benzodiazepines and detoxification with methadone.Mechanism of action of benzodiazepines on GABAA receptors.Structural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulationDesformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 SubunitEstimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits.Tandem couture: Cys-loop receptor concatamer insights and caveats.Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors.Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.Impact of synaptic neurotransmitter concentration time course on the kinetics and pharmacological modulation of inhibitory synaptic currents.GABA transient sets the susceptibility of mIPSCs to modulation by benzodiazepine receptor agonists in rat hippocampal neurons.Clinical Sleep-Wake Disorders II: Focus on Insomnia and Circadian Rhythm Sleep Disorders.The F-loop of the GABA A receptor gamma2 subunit contributes to benzodiazepine modulation.Context dependent benzodiazepine modulation of GABA(A) receptor opening frequencyDocking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site.Flurazepam effect on GABAergic currents depends on extracellular pH.Insomnia disorder.Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA Receptor Activity
P2860
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P2860
Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Benzodiazepine modulation of p ...... llosteric model of modulation.
@ast
Benzodiazepine modulation of p ...... llosteric model of modulation.
@en
type
label
Benzodiazepine modulation of p ...... llosteric model of modulation.
@ast
Benzodiazepine modulation of p ...... llosteric model of modulation.
@en
prefLabel
Benzodiazepine modulation of p ...... llosteric model of modulation.
@ast
Benzodiazepine modulation of p ...... llosteric model of modulation.
@en
P2860
P356
P1476
Benzodiazepine modulation of p ...... llosteric model of modulation.
@en
P2093
Scott S Downing
P2860
P304
P356
10.1038/SJ.BJP.0706251
P407
P577
2005-08-01T00:00:00Z