HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 - Test2 - elhamkhani - TriplyDB

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

http://www.wikidata.org/entity/Q33851502

about

Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency Cellular and viral determinants of retroviral nuclear entry Epigenetic control of HIV-1 post integration latency: implications for therapy Impact of Chromatin on HIV Replication HIV-1 capsid: the multifaceted key player in HIV-1 infection A model for cofactor use during HIV-1 reverse transcription and nuclear entry Retroviral integrations in gene therapy trials The Road Less Traveled: HIV's Use of Alternative Routes through Cellular Pathways Dynamics and restriction of murine leukemia virus cores in mitotic and interphase cells CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication Crystal Structure of the N-Terminal Domain of Nup358/RanBP2 HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358 HIV-1 evades innate immune recognition through specific cofactor recruitment A new class of multimerization selective inhibitors of HIV-1 integrase Bioinformatics and HIV latency.Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection Retroviral DNA Integration The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes Cyclophilins and nucleoporins are required for infection mediated by capsids from circulating HIV-2 primary isolates.Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration.The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.Molecular mechanisms of retroviral integration site selection.Host and viral determinants for MxB restriction of HIV-1 infection.Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy.Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant.Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection.Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells.Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.Host Factors in Retroviral Integration and the Selection of Integration Target Sites.TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.The Role of TNPO3 in HIV-1 Replication.Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.

P2860

Q24295223-BA72C70D-F8FC-4B6E-A3D7-740BCDF83354 Q24300016-A6D87FC4-08BD-4D88-8AEA-AE0A7947C944 Q26778299-AA90D6EC-19B4-4512-921F-07B29A281263 Q26781191-736E1AFC-14C8-471E-8DC7-7CEBB04BFE37 Q26782046-05109D08-973A-4E2A-9DDE-073694073266 Q26801145-23DB5C67-6EBD-4EFA-AEFF-70F5030BF6C0 Q26859218-8369B7CD-89C8-40D0-9B24-427BD0825757 Q26991660-81DC50FE-6708-4410-8FAE-54126798681E Q27027607-16B162E7-97FF-4BAB-A83C-E1D15E873D09 Q27303013-76FA299D-1A7D-4C7E-8C56-0DAF39C1A578 Q27672646-3A6CF0A6-3B43-45E6-931E-A32218EBC058 Q27672780-FF9CE5BC-E965-4325-B14E-6BC815043BF9 Q27679304-B48BAA95-D68B-4C2D-B6AE-C0C7DF1353CE Q27680544-829A5103-6072-423F-8A1E-FFC1F586F932 Q27683994-2C099361-C9AE-4EE7-BBDF-BE0AC15EE94C Q28081427-00BFB221-1DA8-441C-8413-9208BB1B5743 Q28088514-D4974B2A-E1EE-487B-991C-B23A2CE608D5 Q28596842-7EA00D2E-84FB-4842-9D39-AC95C7670FB9 Q28602843-09837CAB-E8CE-4CD3-927C-E8E5AE025D35 Q30400372-7FACF233-6432-4FCB-A0EB-F6CC162B8EDF Q30406846-D621FDF1-62B7-4466-AAA5-701962A30D21 Q30452981-D0A6A855-29DA-4D24-BF3D-4C1297ED8623 Q30459386-C765790E-1D22-45CB-A493-6FD6F17055FB Q31103609-11DA4733-4AC6-45B7-8C7F-CF3DC6E7BDA2 Q34139212-BC365D36-B8B6-493B-9A34-37923101D53A Q34249653-18E332FE-BBE8-46D8-BD47-F27220477EF0 Q34422979-74F8CFF6-A764-4C3E-9C0C-3C6592FF6D45 Q34484917-248967E4-B369-4946-B7FB-FAF67734CAA0 Q34745316-5838D95A-4491-4ED3-8890-0903C75ED9CE Q35018068-602804C9-523F-4C69-8346-711D8754CC05 Q35060475-1CAC6C73-954A-49C4-93FA-AA4E51814632 Q35105663-8105E490-51F6-4CC9-B028-42C331348D2D Q35202343-4E8587A8-6FE5-4942-A314-941155B4158E Q35377316-752C83F6-DE8B-4365-8C59-456691871C67 Q35599400-67DA3A12-1D24-433A-B680-61E08D9D11D6 Q35704078-280EB633-9EB3-4AF8-A6DC-29398C42F669 Q35916677-9AB5CBD8-C69B-4985-8BCA-9F495552D651 Q35943450-C9D192F5-9A4B-4439-8186-D0FD6409C54B Q36131846-E2956497-CF43-4F0B-860A-05CB05ECD574 Q36176014-A7BC3DD5-AA2D-45C6-9AC4-4292D615CBAE

P2860

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

http://www.wikidata.org/entity/Q33851502

description

2011 nî lūn-bûn

@nan

2011 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մարտին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

HIV integration targeting: a p ...... he nuclear pore protein RanBP2

@ast

HIV integration targeting: a p ...... he nuclear pore protein RanBP2

@en

type

label

HIV integration targeting: a p ...... he nuclear pore protein RanBP2

@ast

HIV integration targeting: a p ...... he nuclear pore protein RanBP2

@en

prefLabel

HIV integration targeting: a p ...... he nuclear pore protein RanBP2

@ast

HIV integration targeting: a p ...... he nuclear pore protein RanBP2

@en

P1433

Q33851502-0DB53706-BEC1-4649-8DB2-ED681004C8B2

P1476

Q33851502-7FFE4B0D-9ECB-4CE5-A36B-4B9244BE5DF2

P2093

Q33851502-05C78ACB-F3EC-4F42-AF6C-4524E4297D4D

Q33851502-12FDD75D-36C7-4FEF-8C15-860C998EC12F

Q33851502-7D8EA355-5B6A-44CC-AC9C-FB6B1418FD73

Q33851502-86BF31F9-61B6-45DC-95E5-8DDB6EF8F985

Q33851502-B3024D17-33B0-437C-B973-FF3182E55805

Q33851502-B3DC33B8-5B51-4AAA-BD27-E9E1561DC1CA

Q33851502-B53C3DE7-8B51-4AB6-823F-9770DB4C5355

Q33851502-EC6063D9-79E0-4CFA-B4EC-8583B78337E4

Q33851502-EF0D59FD-61F0-43B3-ABE5-4CDDDEF24C73

P2860

Q33851502-022F2C2B-1684-486B-8370-D2167D441B0B

Q33851502-06E4613F-C7C4-4042-9328-13F361D3C116

Q33851502-0B65DD57-7ECE-428A-BA18-B96B7EB7C121

Q33851502-10AA498E-E213-4667-B5A1-161694C4D545

Q33851502-11861248-1691-4937-9BD5-8351C31971CE

Q33851502-139CE8F2-BD84-4855-A8DD-FBFC41961B41

Q33851502-14E1C8B4-674A-404C-800B-AFD91BC74D63

Q33851502-28B3E8AC-C533-4EBA-A73F-D52FDE11C7F5

Q33851502-28CCF8B6-0D23-423D-BBE5-DC2F0F2138FB

Q33851502-2B0CA043-5B67-469D-8D0D-2F648DB452AB

P304

Q33851502-C8C00E13-EB22-472C-8CCE-8D6DCF20AC38

P31

Q33851502-5DDD76D3-7365-49F9-B79C-B1009D1473FA

P356

Q33851502-FFA8AC6C-FC04-49F6-A505-D3735ACDC251

P433

Q33851502-F79FAA3C-02C3-4FF6-9AC2-074FDA56DEF8

P478

Q33851502-262445DB-2254-49B2-872F-E795E6ACB8AB

P50

Q33851502-15926123-5C5D-49DA-AA3F-CB9E15735752

Q33851502-20F5B911-33C1-4578-96A2-D4B60B2207DA

Q33851502-5D1F183F-E89E-4BAD-B88C-17626BEAC77A

Q33851502-9699D069-33BA-45BC-B2C8-8E5CEA92D68F

Q33851502-F71A08B1-D499-4C93-B5E6-F5BD0D65A34A

P577

Q33851502-7111A192-10AF-46DF-8668-7EC586B09641

P5875

Q33851502-47E68AF1-B354-4C16-B6A1-6DFCC9137229

P698

Q33851502-0FC584CC-0683-40BB-8122-8E40BBFE3937

P932

Q33851502-8FBC5CC3-2D72-497D-AD99-5AEDBAFD036E

P356

JOURNAL.PPAT.1001313

P1433

P1476

HIV integration targeting: a p ...... he nuclear pore protein RanBP2

@en

P2093

Alyssa Huegel

http://www.w3.org/2001/XMLSchema#string

Charles C Berry

http://www.w3.org/2001/XMLSchema#string

John A T Young

http://www.w3.org/2001/XMLSchema#string

Keshet Ronen

http://www.w3.org/2001/XMLSchema#string

Leo C James

http://www.w3.org/2001/XMLSchema#string

Nirav Malani

http://www.w3.org/2001/XMLSchema#string

Shoshannah L Roth

http://www.w3.org/2001/XMLSchema#string

Sumit K Chanda

http://www.w3.org/2001/XMLSchema#string

Troy L Brady

http://www.w3.org/2001/XMLSchema#string

P2860

Initial sequencing and analysis of the human genome

The Sequence of the Human Genome

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

Identification of host proteins required for HIV infection through a functional genomic screen

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

Gene recruitment of the activated INO1 locus to the nuclear membrane

P304

e1001313

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PPAT.1001313

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

Torsten Schaller

Frederic D. Bushman

Karen E Ocwieja

P577

2011-03-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

50597185

http://www.w3.org/2001/XMLSchema#string

P698

21423673

http://www.w3.org/2001/XMLSchema#string

P932

3053352

http://www.w3.org/2001/XMLSchema#string