Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
about
Obesity and insulin resistanceIRS1-independent defects define major nodes of insulin resistanceSelective Insulin Resistance in the KidneyMetabolic actions of Rho-kinase in periphery and brainInsulin in the nervous system and the mind: Functions in metabolism, memory, and moodExercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscleExpression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patientsProtein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cellsFat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance?Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesityOpening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.Losartan increases muscle insulin delivery and rescues insulin's metabolic action during lipid infusion via microvascular recruitment.Effects of diet-induced obesity on protein expression in insulin signaling pathways of skeletal muscle in male Wistar rats.Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolismSpatial compartmentalization of signal transduction in insulin action.Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscleIncreased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice.Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/JngPathogenesis of insulin resistance in skeletal muscle.Molecular mechanism of insulin resistance in obesity and type 2 diabetes.Aerobic exercise plus weight loss improves insulin sensitivity and increases skeletal muscle glycogen synthase activity in older men.Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetesSignaling pathways in insulin action: molecular targets of insulin resistanceSelective PPARĪ³ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice.Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin actionInsulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C.Guava leaf extracts promote glucose metabolism in SHRSP.Z-Leprfa/Izm rats by improving insulin resistance in skeletal muscleFunction and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states.In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes.Invited review: Effects of acute exercise and exercise training on insulin resistance.Chronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and functionMetabolic effects of obesity: A reviewElevated muscle TLR4 expression and metabolic endotoxemia in human aging.Regulation of glucose transport in human skeletal muscle.Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats.An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndromeBariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal.Insulin resistant states and insulin signaling.The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise.
P2860
Q24607078-FFB85499-9598-44E4-BEF4-B73081D8BA1BQ24647774-A3F7ECF8-A923-445A-8CFB-6359BDA1CD38Q26744243-8D131D7E-7870-44DC-B82B-33B43A1B0817Q26864028-4A7F76AA-5179-480C-985A-53966E58E82CQ28079442-0EEDFFBC-3240-4F2C-9792-4BC86E13EF20Q28294805-61EC0626-C444-447B-BBCC-59A2D4EA56F5Q28363309-00923A77-6121-4A84-8A4E-CDB5D9DD29F4Q28565306-D5715FD2-2517-4CC5-8B23-3A197C756C10Q28744500-36D36C91-285B-4CDB-9536-3956F58D3E07Q30278865-373C1E34-CF85-4957-B1EF-23E61E5DE618Q30414295-40E4AE45-D2E4-435E-ACCF-7A4E4FF20495Q30414452-C14B0A06-2354-4532-A7C5-CC43BA107B55Q30420069-B29E2038-E813-466C-973D-F8F2F264894AQ30447386-681536B2-DC4B-4F2F-9B28-C47AC0A34AFFQ32063485-9FD339EA-E180-4D30-9F89-F39B223D8FE4Q33569169-7571ECC8-FD8C-40AD-9C8B-AC807B680D2EQ33643662-F248792F-E023-4326-B533-4C819AA4EB56Q33750765-5220432C-2547-4486-BE2B-6676E2CD32BAQ33785779-0C3791CA-F1C3-4310-81B8-D3864F800839Q33812448-862556B3-B6C1-4B50-A945-BABAFBBC9449Q33893897-D256F3A4-E574-4C0E-AC5E-B4158230AF6BQ33952623-6BAE5149-31E7-43A3-81D1-75860C0C9586Q33959129-888FD9A8-FB57-4CC4-BD61-DCF3F53E49E7Q33973814-DF1686B8-9063-485E-ACCB-C4DB413AF025Q33976093-2AD24DE1-E66D-43F7-9EBF-229DE8AB970CQ34181813-B3BAC343-581E-4864-81ED-50B3CD8E88E2Q34460969-F283588D-E873-4D1A-B3C0-F89F2D22EABAQ34604686-3D8F128A-AB10-4A95-8A85-FC0E355AA68CQ34688703-CBF92966-43D8-4FC8-AC34-60A77A1B75F2Q34718208-1009F75A-BBE1-4742-9F93-4DC997D816D5Q34754988-C7A4A2E3-1FF7-409C-A9F4-79F0475F3573Q34785071-BA1FAEBA-445F-4766-9620-DD2279CFB5A2Q34877856-8EDD1CFB-6E55-4D6D-AD38-C5A2021F941AQ35029353-A24648E5-E95E-4E96-82C6-B5DD8CE1F9BBQ35043409-395D00FD-F190-46F0-A321-26AAF3F11B34Q35049153-B88B9F6D-EA56-4324-BF6D-6AF2C4C5E9F1Q35213260-3D970061-68C3-45A9-AEAF-AF81858FACF0Q35393067-ACD04602-3BFB-4732-89B2-E67886FB0A7BQ35576057-34418187-623A-4941-81AD-B3884E736045Q35642128-9A33DD23-C8B5-4898-B740-26E1F09732B5
P2860
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
description
1999 nĆ® lÅ«n-bĆ»n
@nan
1999 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ„ÕŗÕæÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
Õ¤ÕøÖÕ”Õ®
@hyw
1999 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ½Õ„ÕŗÕæÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
1999幓ć®č«ę
@ja
1999幓č«ę
@yue
1999幓č«ę
@zh-hant
1999幓č«ę
@zh-hk
1999幓č«ę
@zh-mo
1999幓č«ę
@zh-tw
1999幓č®ŗę
@wuu
name
Normal insulin-dependent activ ...... , in muscle in type 2 diabetes
@ast
Normal insulin-dependent activ ...... , in muscle in type 2 diabetes
@en
type
label
Normal insulin-dependent activ ...... , in muscle in type 2 diabetes
@ast
Normal insulin-dependent activ ...... , in muscle in type 2 diabetes
@en
prefLabel
Normal insulin-dependent activ ...... , in muscle in type 2 diabetes
@ast
Normal insulin-dependent activ ...... , in muscle in type 2 diabetes
@en
P2093
P2860
P356
P1476
Normal insulin-dependent activ ...... , in muscle in type 2 diabetes
@en
P2093
S E Nikoulina
T P Ciaraldi
P2860
P304
P356
10.1172/JCI6928
P407
P577
1999-09-01T00:00:00Z