Current status on Alzheimer disease molecular genetics: from past, to present, to future. - Test2 - elhamkhani - TriplyDB

Current status on Alzheimer disease molecular genetics: from past, to present, to future.

Current status on Alzheimer disease molecular genetics: from past, to present, to future.

http://www.wikidata.org/entity/Q33871345

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Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease Interactome mapping suggests new mechanistic details underlying Alzheimer's disease Synapses and Alzheimer's disease Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores Physiological and pathological phosphorylation of tau by Cdk5 The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization Anti-aggregating effect of the naturally occurring dipeptide carnosine on aβ1-42 fibril formation Amyloid oligomer neurotoxicity, calcium dysregulation, and lipid rafts Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.Drug development status for Alzheimer's disease: present scenario.Genetics of dementia.Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease.A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease.Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study.Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease.Drug development for Alzheimer's disease: recent progress Structural and mechanistic commonalities of amyloid-β and the prion protein Discovering Alzheimer Genetic Biomarkers Using Bayesian Networks.Amyloid deposition and advanced age fails to induce Alzheimer's type progression in a double knock-in mouse model No Associations Found between PGBD1 and the Age of Onset in Japanese Patients Diagnosed with Sporadic Alzheimer's Disease Developmental regulation of expression of schizophrenia susceptibility genes in the primate hippocampal formation.Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice Genetic Association between Neurotrophin-3 Polymorphisms and Alzheimer's Disease in Japanese Patients Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.Novel drug targets based on metallobiology of Alzheimer's disease.Genetics of Alzheimer's disease: an insight into presenilins and apolipoprotein E instigated neurodegeneration.Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges.Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis.Lessons from genome-wide association studies findings in Alzheimer's disease.The potential role of rho GTPases in Alzheimer's disease pathogenesis.Research and development of anti-Alzheimer's drugs: an analysis based on technology flows measured by patent citations.Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration.The relationship between amyloid deposition, neurodegeneration, and cognitive decline in dementia.Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients.Is AD a homogeneous nosologic entity? Yes.Association between EXOC3L2 rs597668 polymorphism and Alzheimer's disease.

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P2860

Current status on Alzheimer disease molecular genetics: from past, to present, to future.

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Current status on Alzheimer disease molecular genetics: from past, to present, to future.

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Current status on Alzheimer disease molecular genetics: from past, to present, to future.

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Role of Genes and Environments for Explaining Alzheimer Disease

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

Evidence for CALM in directing VAMP2 trafficking

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Genome-wide association studies in Alzheimer's disease

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

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