The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.
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Diazo Compounds: Versatile Tools for Chemical BiologyIdentification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolitesThe large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.Reactivity of Nucleic Acid Radicals.Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair.Analysis of diazofluorene DNA binding and damaging activity: DNA cleavage by a synthetic monomeric diazofluoreneThe marine actinomycete genus Salinispora: a model organism for secondary metabolite discoveryDouble-strand breaks from a radical commonly produced by DNA-damaging agents.Multigram Synthesis of 1-O-Acetyl-3-O-(4-methoxybenzyl)-4-N-(9-fluorenylmethoxycarbonyl)-4-N-methyl-L-pyrrolosamine.A ROS-Activatable Agent Elicits Homologous Recombination DNA Repair and Synergizes with Pathway CompoundsIdentification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesisCharacterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome MiningStructural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin AMechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Mechanism of Nucleophilic Activation of (-)-Lomaiviticin A.Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation.Mycofumigation by the volatile organic compound-producing Fungus Muscodor albus induces bacterial cell death through DNA damage.Nucleotide excision repair of chemically stabilized analogues of DNA interstrand cross-links produced from oxidized abasic sites.Production of Stealthin C Involves an S-N-Type Smiles Rearrangement.Probing Enhanced Double-Strand Break Formation at Abasic Sites within Clustered Lesions in Nucleosome Core Particles.The Mechanism of Action of (-)-Lomaiviticin A.Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines.
P2860
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P2860
The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.
description
2014 nî lūn-bûn
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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年学术文章
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2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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name
The cytotoxicity of (-)-lomaiv ...... f double-strand breaks in DNA.
@ast
The cytotoxicity of (-)-lomaiv ...... f double-strand breaks in DNA.
@en
type
label
The cytotoxicity of (-)-lomaiv ...... f double-strand breaks in DNA.
@ast
The cytotoxicity of (-)-lomaiv ...... f double-strand breaks in DNA.
@en
prefLabel
The cytotoxicity of (-)-lomaiv ...... f double-strand breaks in DNA.
@ast
The cytotoxicity of (-)-lomaiv ...... f double-strand breaks in DNA.
@en
P2093
P2860
P356
P1433
P1476
The cytotoxicity of (-)-lomaiv ...... of double-strand breaks in DNA
@en
P2093
Christina M Woo
Denise C Hegan
Laureen C Colis
Seth B Herzon
P2860
P2888
P304
P356
10.1038/NCHEM.1944
P577
2014-05-11T00:00:00Z
P5875
P6179
1008714353