MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. - Test2 - elhamkhani - TriplyDB

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q33878853

about

Toward precision medicine in amyotrophic lateral sclerosis Autophagy and neurodegeneration Trehalose Accumulation Triggers Autophagy during Plant Desiccation Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach Essential role for autophagy in life span extension Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control Interplay of Oxidative Stress and Autophagy in PAMAM Dendrimers-Induced Neuronal Cell Death mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms.Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment.Trehalose-mediated autophagy impairs the anti-viral function of human primary airway epithelial cells.Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis.Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.mRNP granules. Assembly, function, and connections with disease.p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types.Current Therapy of Drugs in Amyotrophic Lateral Sclerosis.Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway.Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression.Preservation of Cognitive Function by Lepidium meyenii (Maca) Is Associated with Improvement of Mitochondrial Activity and Upregulation of Autophagy-Related Proteins in Middle-Aged Mouse Cortex SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.Targeting the unfolded protein response for disease intervention.mTOR in Brain Physiology and Pathologies.Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism.Old versus New Mechanisms in the Pathogenesis of ALS.A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy.Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases.Target acquired: Selective autophagy in cardiometabolic disease.Autophagy in neurodegenerative diseases: pathogenesis and therapy.mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1.Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis.Cell Death-Autophagy Loop and Glutamate-Glutamine Cycle in Amyotrophic Lateral Sclerosis.Trehalose May Decrease the Transmission of Zika Virus to the Fetus by Activating Degradative Autophagy.Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis.

P2860

Q26764950-441CEC7D-622A-469A-8716-DF9FA3D7AF89 Q26991692-D0E5D145-8240-47C1-86BA-8F8FD1C55E5A Q27309959-239B1986-D21E-4ADB-BD3C-8537348AF5BF Q28084605-41FA89F8-6B26-40DD-8BB8-EC8FD2549F9B Q28085050-5392F338-662A-4DFF-897E-436AF52B08CD Q28391199-D552D33A-ACE4-42DE-902E-101B89B6A20E Q28391784-BAECA68C-DD85-45BA-B5F8-BC9377E20E98 Q30838293-316CADC5-3739-4D11-8B20-37A55248C28F Q33621868-DF38F5C2-D347-4052-AFCC-FCA6A93B00F1 Q33796347-35DC5BA6-8E59-48D4-8928-11011B9C3198 Q33808745-77CF6CD5-2EAD-4AA5-9A1F-FAC4FA65BDE1 Q33819258-ED2AFC8C-747F-4C3D-BBEC-53B39A96EDD7 Q34673417-0D339580-F616-4567-A327-6F5E995317DD Q35064974-F3093DF4-74F6-4388-A917-315B735B5995 Q35439721-1E607D8B-3DF5-4BC1-986B-F3341C5B0B67 Q35448331-714C298E-B751-43C4-A2EA-1C3EF534A4FB Q35588631-91418961-58C8-4BC4-895B-7265B0D9941E Q35899260-EAA27EB4-82F6-40A4-A042-BF4CA7229D55 Q36061223-1E83334E-B142-434C-8C64-F0CD028F53BA Q36189835-AC84B163-688F-4D00-BE25-86A2C42FDF6C Q36246261-AD3A373D-D490-4D0E-9DAC-D20FFE76F76E Q36481533-885EFDC3-05B8-4F60-994E-09AB176064DE Q36925891-01A787E7-AADB-4F1E-836B-A47E7B8C92F6 Q37027667-722CF646-31E8-4B9C-B60E-DE60CCB9CD27 Q37196234-2B8D9FCF-4102-4DC7-97EC-B6F97DFAAAA4 Q37246557-967CA736-28DD-4FD4-931D-1740EDCA60F9 Q37476025-D6F51975-F4A2-4ADD-9891-5DC331E0D5A0 Q38545670-D1E73B2F-9A9E-4D46-B712-434E43A91678 Q38565769-4F882AE2-A028-4D8C-AD0F-2FE0F8AE5D80 Q38682634-E5BC75E6-7E06-44C6-B386-5278EA92F9E6 Q38700722-DFCA820B-6AA7-46F9-8693-FA67528CAADF Q38731909-8F6DC6DF-401C-4B4F-8A0F-71A7723D8DCF Q38840491-76E0058E-A9B8-4FDA-9341-B47363720C62 Q39155198-0CFA1B28-6E52-407A-A25C-E88E2B404657 Q39432638-B20D3731-1F18-4833-A92A-383FD148B1CB Q39641749-4DEFC8A5-8C17-4B8A-B67B-120E7051A3A6 Q40127266-FBC4F810-B835-4774-8F14-64D433755B16 Q41074384-396C06F1-C93F-4F08-ADC3-8003B0627DC3 Q41440488-C1256EB7-0D95-477F-AEA3-D662FC5CC23F Q41465422-B4595974-03D4-4A21-A9F2-EB05F7BA389D

P2860

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q33878853

description

2014 nî lūn-bûn

@nan

2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.

@ast

MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.

@en

type

label

MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.

@ast

MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.

@en

prefLabel

MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.

@ast

MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis.

@en

P1433

Q33878853-89CBC792-98D6-4761-B952-B0A481BFD690

P1476

Q33878853-C3D71E0A-A933-48C9-89A0-A5027E2F00CF

P2093

Q33878853-09446A9A-5602-4427-953C-645FD84CDF6A

Q33878853-C070632B-F09B-4ABF-8510-95B3317BC885

Q33878853-D075BFFB-192B-493C-96CE-74D1B24C2572

Q33878853-E35C31D4-5B9E-4318-93B8-6DABA1DD4795

Q33878853-F0D794BC-B103-4C0E-8DDE-B89524D29A95

Q33878853-FA2880C5-4205-4468-BAD1-6146222D210F

P2860

Q33878853-0018F6BA-8FAB-4506-A9C4-A3D928C1628A

Q33878853-0AF1FDB0-0D97-40F5-B473-25BDF31C1A88

Q33878853-1397A6D7-4471-44F1-A14E-4152BAA2254D

Q33878853-204350C9-BB85-431C-8406-6A322BE553C4

Q33878853-2F08EA14-7723-4E1A-A4F2-628893E116B0

Q33878853-31F6EC81-ED72-427B-AE63-37193FABC78C

Q33878853-43180D87-78C7-4898-820A-6D7A03020D12

Q33878853-4C0B9340-080E-47AB-8D59-4DD29FB16A34

Q33878853-4FE48DE0-3BD0-4702-B541-678F8A6CD0D1

Q33878853-522964C0-0660-4058-8430-BD3C99580145

P304

Q33878853-B19A7E46-4001-4668-8E71-F2D9E852C2BF

P31

Q33878853-132A24BB-0056-4EED-8A80-D71DFDEF5EB1

P356

Q33878853-BF025B70-8736-4FF0-BC4D-F4354051AC25

P433

Q33878853-CFD7C9F0-E3C1-4095-8E2D-E7310DEA0DF6

P478

Q33878853-1892AED6-4E6F-46A9-BB90-1028D5E44125

P50

Q33878853-AB428A2C-D4AB-454D-8DB1-AD33544151F3

P577

Q33878853-CD6C9478-6C8A-40F6-B289-1850ED30ADB7

P5875

Q33878853-9FD37180-A482-4B17-B1D0-01D3C35BA355

P698

Q33878853-5331980D-8D6F-46B8-BD1D-D3FF66BF4811

P921

Q33878853-07AECD1B-9956-4447-884C-29E559E0A048

Q33878853-3B3082E2-2682-4B47-AB73-FC58AA2D44FE

Q33878853-79886871-6B77-4695-8CCC-76C4D3FF0D8E

P932

Q33878853-49A0A43D-3226-4901-8C68-2FD6525E0A92

P356

P1433

P1476

MTOR-independent, autophagic e ...... amyotrophic lateral sclerosis

@en

P2093

Li Jia

http://www.w3.org/2001/XMLSchema#string

Lin Song

http://www.w3.org/2001/XMLSchema#string

Weidong Le

http://www.w3.org/2001/XMLSchema#string

Xiaojie Zhang

http://www.w3.org/2001/XMLSchema#string

Yu Tang

http://www.w3.org/2001/XMLSchema#string

Yufei Shen

http://www.w3.org/2001/XMLSchema#string

P2860

Guidelines for the use and interpretation of assays for monitoring autophagy

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion.

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

Methods in mammalian autophagy research

P304

588-602

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.4161/AUTO.27710

http://www.w3.org/2001/XMLSchema#string

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

10

http://www.w3.org/2001/XMLSchema#string

P50

P577

2014-01-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

259807461

http://www.w3.org/2001/XMLSchema#string

P698

24441414

http://www.w3.org/2001/XMLSchema#string

P921

amyotrophic lateral sclerosis

alpha,alpha-trehalose

P932

4091147

http://www.w3.org/2001/XMLSchema#string