Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017.
about
Insights into novel antimicrobial compounds and antibiotic resistance genes from soil metagenomesTargeted metagenomics: finding rare tryptophan dimer natural products in the environmentScreening for genes coding for putative antitumor compounds, antimicrobial and enzymatic activities from haloalkalitolerant and haloalkaliphilic bacteria strains of Algerian Sahara SoilsBiosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes.Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.Metagenomic small molecule discovery methods.Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.Mutations in the proteolipid subunits of the vacuolar H+-ATPase provide resistance to indolotryptoline natural products.Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environmentCharacterization of an environmental DNA-derived gene cluster that encodes the bisindolylmaleimide methylarcyriarubinDiversity and biotechnological potential of microorganisms associated with marine sponges.Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.Inhibition of the growth of Bacillus subtilis DSM10 by a newly discovered antibacterial protein from the soil metagenome.Drug discovery from marine microbes.Metagenomics and novel gene discovery: promise and potential for novel therapeutics.Alternative hosts for functional (meta)genome analysis.Culture-independent discovery of natural products from soil metagenomes.Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.Native and engineered promoters in natural product discovery.Expansion of bisindole biosynthetic pathways by combinatorial construction.Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032.Reconstruction of cladoniamide biosynthesis reveals nonenzymatic routes to bisindole diversity.Antimicrobial potential and taxonomic investigation of piezotolerant Streptomyces sp. NIOT-Ch-40 isolated from deep-sea sediment.Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis.NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species
P2860
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P2860
Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Cloning and characterization o ...... antitumor substance BE-54017.
@ast
Cloning and characterization o ...... antitumor substance BE-54017.
@en
type
label
Cloning and characterization o ...... antitumor substance BE-54017.
@ast
Cloning and characterization o ...... antitumor substance BE-54017.
@en
prefLabel
Cloning and characterization o ...... antitumor substance BE-54017.
@ast
Cloning and characterization o ...... antitumor substance BE-54017.
@en
P2860
P356
P1476
Cloning and characterization o ...... antitumor substance BE-54017.
@en
P2093
Fang-Yuan Chang
Sean F Brady
P2860
P304
P356
10.1021/JA2022653
P407
P577
2011-05-04T00:00:00Z