Combinatorial biosynthesis of antitumor indolocarbazole compounds - Test2 - elhamkhani - TriplyDB

Combinatorial biosynthesis of antitumor indolocarbazole compounds

Combinatorial biosynthesis of antitumor indolocarbazole compounds

http://www.wikidata.org/entity/Q24557524

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Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243 Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton Microwave-assisted Piloty-Robinson synthesis of 3,4-disubstituted pyrroles Marine natural products as breast cancer resistance protein inhibitors Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC The FAD Cofactor of RebC Shifts to an IN Conformation upon Flavin Reduction † , ‡The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes Synthetic biology to access and expand nature's chemical diversity Targeted metagenomics: finding rare tryptophan dimer natural products in the environment Registry in a tube: multiplexed pools of retrievable parts for genetic design space exploration.Natural-product sugar biosynthesis and enzymatic glycodiversification.Chemically engineered extracts as an alternative source of bioactive natural product-like compounds.Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase.Metabolic engineering for the production of natural products.Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017.Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.Regioselective arene halogenation using the FAD-dependent halogenase RebH.Directed evolution of RebH for site-selective halogenation of large biologically active molecules.Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners.RebG- and RebM-catalyzed indolocarbazole diversification.Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.Divergent pathways in the biosynthesis of bisindole natural products.Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine.Total (bio)synthesis: strategies of nature and of chemists.Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment Characterization of an environmental DNA-derived gene cluster that encodes the bisindolylmaleimide methylarcyriarubin Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691 Bioprospecting potential of halogenases from Arctic marine actinomycetes.Crystallography gets the jump on the enzymologists A comprehensive review of glycosylated bacterial natural products.Expression, purification and preliminary X-ray diffraction studies of RebC.Cloning, characterization and heterologous expression of the indolocarbazole biosynthetic gene cluster from marine-derived Streptomyces sanyensis FMA."Head-to-side-chain" cyclodepsipeptides of marine origin.Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria Antitumor compounds from marine actinomycetes.Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by actinomycetes.

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

http://www.wikidata.org/entity/Q24557524

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2005年の論文

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name

Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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type

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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PNAS.0407809102

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Proceedings of the National Academy of Sciences of the United States of America

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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P2093

Aaroa P Salas

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José A Salas

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Jürgen Rohr

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Lili Zhu

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P2860

Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia.

Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication

New colorimetric cytotoxicity assay for anticancer-drug screening

The biosynthesis of indolocarbazoles in a heterologous E. coli host.

Microbial biosynthesis of halometabolites.

UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century?

Altering the glycosylation pattern of bioactive compounds.

Calories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition.

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

Modification of post-PKS tailoring steps through combinatorial biosynthesis.

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10.1073/PNAS.0407809102

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2

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102

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Alfredo F. Braña

César Sánchez

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8106073

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15625109

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