The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
about
Cellular roles of dna topoisomerases: a molecular perspectiveStructure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genesExcision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteinsThe Bloom's and Werner's syndrome proteins are DNA structure-specific helicasesIdentification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1Asymmetry of DNA replication fork progression in Werner's syndromeGenome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulationRoles of RECQ helicases in recombination based DNA repair, genomic stability and agingThe C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stabilityCompetition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteinsThe RNA helicase A in malignant transformationMetabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null MiceMutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae.Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase AReconstitution of human DNA polymerase delta using recombinant baculoviruses: the p12 subunit potentiates DNA polymerizing activity of the four-subunit enzymePotential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51RecQ helicases: caretakers of the genomeWerner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domainsSelective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.Loss of Werner syndrome protein function promotes aberrant mitotic recombination.Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: studies of fusion proteins.Interactions of DNA helicases with damaged DNA: possible biological consequences.WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex.Homologous recombination resolution defect in werner syndrome.Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span.Telomeres, chromosome instability and cancerEvolution and organization of a highly dynamic, subtelomeric helicase gene family in the rice blast fungus Magnaporthe griseaSlx1-Slx4 are subunits of a structure-specific endonuclease that maintains ribosomal DNA in fission yeast.Vitamin C restores healthy aging in a mouse model for Werner syndromeMutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid featuresRoles of RecQ family helicases in the maintenance of genome stability.Genes and pathways driving glioblastomas in humans and murine disease models.The landscape of transposable elements in the finished genome of the fungal wheat pathogen Mycosphaerella graminicolaAge related expression of Werner's syndrome protein in selected tissues and coexpression of transcription factors.A Novel WRN Frameshift Mutation Identified by Multiplex Genetic Testing in a Family with Multiple Cases of Cancer
P2860
Q22121990-A214E0FC-F9C4-4BC3-8E10-C02E537FDAE4Q24291021-5C5FA823-48AC-4EAF-B2FF-E527A0C0FFC8Q24291054-0931F39C-1652-49B0-858D-6650A3A49E68Q24291390-E34BDE79-B8E1-472C-B981-A01FB8E654BBQ24305550-DDF40843-EB59-4B2E-9DB6-F7E84F3D6D17Q24311409-6FE23205-1B23-480B-8A34-54DF02BA569EQ24546080-E27E3B3A-3BB0-442E-AA8F-6888D69743D9Q24646853-BE62EA1B-2225-4A5C-A96D-45C5C86D6133Q24801293-B932E3B9-0DA8-45B0-BC6C-CC09C0BD1522Q25257333-413565B3-595B-4967-9812-863C6F502E63Q26765181-2ADE3BF9-5F0D-4952-9934-10A4C9B9E1DFQ27313716-4757E513-66DF-489C-B83A-FC14E8233819Q27931991-47B8066A-F892-4064-A948-D13F6557D259Q28116259-7A81148B-AA56-4F97-9A9B-D3964707F464Q28204839-0B3CCA74-0961-4492-ABF3-749EA1990266Q28205766-7F95EF08-54E3-4146-86BF-9287678F0363Q28207894-B857DE4D-E2B7-4165-8A72-DD639D6C7F40Q29618390-7AF4D191-AF43-4E21-91B0-B832B63F088CQ30990769-89CFAB40-5385-4B25-9594-D424E9AB520AQ33234879-1929DC88-6050-4275-93D1-3E569A53E929Q33616272-D90751A7-8A20-4A21-A408-0E6626B55DD7Q33786685-35FBB9BB-4759-49F1-AA50-A2F53332322FQ33943676-C7E48BD6-3ABE-4039-9FE7-61C3DA66C056Q33944087-2F128ECA-F008-4DF2-A950-600E67238F10Q33944291-40D90B4D-D5ED-437F-AA71-A61AF1403EF0Q34011942-9765001B-2BBF-4C74-8F85-E8C09E2AA8B0Q34125040-CCEA39E5-50B8-4CA1-B712-B172E5FA17C5Q34150355-B1CC6EAB-A5C3-4FAB-A83A-F3C1113F976DQ34182444-ECD58B88-9370-432B-8F1F-3355765C6ED2Q34460106-A1C16E54-11DC-44E6-AE09-C56174851E43Q34595437-598431D1-65B4-4574-907D-9835B3AEDFD9Q34615826-6E0B2F95-3184-4025-8F6B-4593E2C3778CQ34785526-07CECE8C-D769-45C6-A098-0C27A85F6C0CQ35001920-2CA76FD4-44D1-4A61-9ED3-F2C9871C2244Q35129273-84EA9EED-8D51-4F4F-B0B4-0BB4767E2758Q35132675-D71AAF00-7077-482C-9246-968AFD00B9EEQ35143797-EDE5E7A8-F989-4DA6-9D97-ABD8BCEB6137Q35528859-C7CCCD88-3C99-41B6-A186-ACED5C56C011Q35586023-07441A6B-B0E8-4FBF-8BD5-CCEDB76C5A37Q35737508-F413324F-6385-492C-B5BB-F58031613DBC
P2860
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
@ast
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
@en
type
label
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
@ast
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
@en
prefLabel
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
@ast
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
@en
P1433
P1476
The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
@en
P2093
P304
P356
10.1016/S0168-9525(99)01970-8
P577
2000-05-01T00:00:00Z