Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway.

Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway.

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http://www.wikidata.org/entity/Q33899529

Q33899529

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Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2 MEK5/ERK5 pathway: the first fifteen years Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12.A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR).Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning.Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C.Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion G protein regulation of MAPK networks.The role of shear stress on ET-1, KLF2, and NOS-3 expression in the developing cardiovascular system of chicken embryos in a venous ligation model.ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.Role of G12 proteins in oncogenesis and metastasis Treatment with 17β-Estradiol Reduced Body Weight and the Risk of Cardiovascular Disease in a High-Fat Diet-Induced Animal Model of Obesity.Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB.MAPK7 gene controls proliferation, migration and cell invasion in osteosarcoma.ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expression.c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy.Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor.Effect of ethanol on protein kinase Czeta and p70S6 kinase activation by carbachol: a possible mechanism for ethanol-induced inhibition of glial cell proliferation.Undermining the endothelium by ablation of MAPK-MEF2 signaling.Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms.Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.Regulation of c-Fos and Fra-1 by the MEK5-ERK5 pathway.Radixin stimulates Rac1 and Ca2+/calmodulin-dependent kinase, CaMKII: cross-talk with Galpha13 signaling.Activation of a C-terminal transcriptional activation domain of ERK5 by autophosphorylation.Regulation of c-myc expression by PDGF through Rho GTPases.Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2.

P2860

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P2860

Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway.

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