Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations.
about
Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinACellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastinThe early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitroThe dystonia-associated protein torsinA modulates synaptic vesicle recyclingBiosynthesis of the dystonia-associated AAA+ ATPase torsinA at the endoplasmic reticulumEffect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutantThe early onset dystonia protein torsinA interacts with kinesin light chain 1Arresting a Torsin ATPase reshapes the endoplasmic reticulumLULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutationTorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeletonUnscrambling an egg: protein disaggregation by AAA+ proteinsTorsins: not your typical AAA+ ATPasesDystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelopeA molecular mechanism underlying the neural-specific defect in torsinA mutant miceTorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegenerationChemical enhancement of torsinA function in cell and animal models of torsion dystonia.The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component.Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia.TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast.Biochemical and cellular analysis of human variants of the DYT1 dystonia protein, TorsinA/TOR1AThe early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response.Current Gaps in the Understanding of the Subcellular Distribution of Exogenous and Endogenous Protein TorsinA.A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding.TorsinA in the nuclear envelope.Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells.Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunctionTorsinA and torsion dystonia: Unraveling the architecture of the nuclear envelope.Intracellular complexes of the early-onset torsion dystonia-associated AAA+ ATPase TorsinA.Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum.Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice.Inherited isolated dystonia: clinical genetics and gene function.Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress.An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.Motor deficits and hyperactivity in Dyt1 knockdown mice.A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders.Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits.The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy.
P2860
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P2860
Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations.
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Torsin A and its torsion dysto ...... nct subcellular localizations.
@ast
Torsin A and its torsion dysto ...... nct subcellular localizations.
@en
type
label
Torsin A and its torsion dysto ...... nct subcellular localizations.
@ast
Torsin A and its torsion dysto ...... nct subcellular localizations.
@en
prefLabel
Torsin A and its torsion dysto ...... nct subcellular localizations.
@ast
Torsin A and its torsion dysto ...... nct subcellular localizations.
@en
P2093
P356
P1476
Torsin A and its torsion dysto ...... nct subcellular localizations.
@en
P2093
P304
27933-27939
P356
10.1074/JBC.M910025199
P407
P577
2000-09-01T00:00:00Z