Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
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Tracking murine gammaherpesvirus 68 infection of germinal center B cells in vivoInhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency.The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiationRTA promoter demethylation and histone acetylation regulation of murine gammaherpesvirus 68 reactivationMurine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome.Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient miceThe viral latency-associated nuclear antigen augments the B-cell response to antigen in vivoA gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge.Identification of spliced gammaherpesvirus 68 LANA and v-cyclin transcripts and analysis of their expression in vivo during latent infectionHelminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cellsORF18 is a transfactor that is essential for late gene transcription of a gammaherpesvirus.Evidence for CDK-dependent and CDK-independent functions of the murine gammaherpesvirus 68 v-cyclin.Establishment of murine gammaherpesvirus latency in B cells is not a stochastic event.Tiled microarray identification of novel viral transcript structures and distinct transcriptional profiles during two modes of productive murine gammaherpesvirus 68 infection.Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection.Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade.Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latencyNF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency.Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent proteinMurine gammaherpesvirus 68 reactivation from B cells requires IRF4 but not XBP-1.Use of a virus-encoded enzymatic marker reveals that a stable fraction of memory B cells expresses latency-associated nuclear antigen throughout chronic gammaherpesvirus infection.Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and antiviral antibody responses.A replication-defective gammaherpesvirus efficiently establishes long-term latency in macrophages but not in B cells in vivo.
P2860
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P2860
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
@ast
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
@en
type
label
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
@ast
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
@en
prefLabel
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
@ast
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
@en
P2093
P2860
P1433
P1476
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
@en
P2093
Christopher B Wilson
Janice M Moser
Jason W Upton
Robert D Allen
Samuel H Speck
P2860
P304
P356
10.1128/JVI.79.15.9480-9491.2005
P577
2005-08-01T00:00:00Z