Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
about
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsInterleukin-2 receptor signaling: at the interface between tolerance and immunityShared and distinct genetic variants in type 1 diabetes and celiac diseaseA genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21Central role of defective interleukin-2 production in the triggering of islet autoimmune destructionRobust associations of four new chromosome regions from genome-wide analyses of type 1 diabetesNewly identified genetic risk variants for celiac disease related to the immune responseInducing and Administering Tregs to Treat Human DiseaseThe Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple SclerosisLow-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunityFrom IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokinesRecent advances in the genetics of autoimmune diseaseCellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5IL-21: roles in immunopathology and cancer therapyEvidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic miceRegulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding TrialAssociation of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern SwedenIL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsRegulatory T cells and vasectomyH2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune diseaseRegulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomyGenetics of type 1 diabetes: what's next?IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes.Prioritizing genes of potential relevance to diseases affected by sex hormones: an example of myasthenia gravisDiscovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity.Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation.Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cellsOnce a Treg, always a Treg?Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjectsFine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate gene regulating experimental neuroinflammation in rat.Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial.Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes.Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.
P2860
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P2860
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
@ast
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
@en
type
label
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
@ast
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
@en
prefLabel
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
@ast
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
@en
P2093
P2860
P356
P1433
P1476
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
@en
P2093
Andrea Gonzalez-Munoz
Anne Marie Cumiskey
Barry Healy
Dan Rainbow
David V Serreze
Jane Rogers
Jun Yamanouchi
Kara Hunter
Laurence B Peterson
P2860
P2888
P304
P356
10.1038/NG1958
P407
P577
2007-02-04T00:00:00Z