Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea
about
Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342Formation and persistence of 8-oxoguanine in rat lung cells as an important determinant for tumor formation following particle exposureTranscriptional bypass of regioisomeric ethylated thymidine lesions by T7 RNA polymerase and human RNA polymerase II.Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.Crystal and solution structures of d(CGC[e6G]AATTCGCG)-drug complexes reveal conformational polymorphism of O6-ethyl-guanine:cytosine base pair.Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes.Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors.Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences.High susceptibility of analbuminemic rats to neurogenic tumor induction by transplacental administration of N-ethyl-N-nitrosourea.N -ethyl- N -nitrosourea induces retinal photoreceptor damage in adult ratsp53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine.Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol.Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT.Protection against malignant progression of spontaneously developing liver tumors in transgenic mice expressing O(6)-methylguanine-DNA methyltransferase.
P2860
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P2860
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea
description
1990 nî lūn-bûn
@nan
1990 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
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1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
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name
Repair of O6-ethylguanine in D ...... rsion by N-ethyl-N-nitrosourea
@ast
Repair of O6-ethylguanine in D ...... rsion by N-ethyl-N-nitrosourea
@en
type
label
Repair of O6-ethylguanine in D ...... rsion by N-ethyl-N-nitrosourea
@ast
Repair of O6-ethylguanine in D ...... rsion by N-ethyl-N-nitrosourea
@en
prefLabel
Repair of O6-ethylguanine in D ...... rsion by N-ethyl-N-nitrosourea
@ast
Repair of O6-ethylguanine in D ...... rsion by N-ethyl-N-nitrosourea
@en
P2093
P2860
P356
P1476
Repair of O6-ethylguanine in D ...... rsion by N-ethyl-N-nitrosourea
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.24.9883
P407
P577
1990-12-01T00:00:00Z