Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. - Test2 - elhamkhani - TriplyDB

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.

http://www.wikidata.org/entity/Q33946936

about

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly Chronic Hepatitis C Infection in Children: Current Treatment and New Therapies Structures of hepatitis C virus nonstructural proteins required for replicase assembly and function Direct acting antivirals for the treatment of chronic viral hepatitis The Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious Virus Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain Formation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B protein An Amphipathic -Helix at the C Terminus of Hepatitis C Virus Nonstructural Protein 4B Mediates Membrane Association Hepatitis C: recent successes and continuing challenges in the development of improved treatment modalities Mutations in Classical Swine Fever Virus NS4B Affect Virulence in Swine Massively parallel measurements of molecular interaction kinetics on a microfluidic platform.Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein Chip in a lab: Microfluidics for next generation life science research.Examining the interactions of the splicing factor MBNL1 with target RNA sequences via a label-free, multiplex method RNA-protein binding kinetics in an automated microfluidic reactor An in vitro microfluidic approach to generating protein-interaction networks Current and future therapies for hepatitis C virus infection.A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins.New antiviral therapies for chronic hepatitis C ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication.Hepatitis C virus experimental model systems and antiviral drug research.Particles and microfluidics merged: perspectives of highly sensitive diagnostic detection.Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase.Programmable and automated bead-based microfluidics for versatile DNA microarrays under isothermal conditions.Experimental strategies for studying transcription factor-DNA binding specificities.Computational modeling of mammalian signaling networks.New strategies for the treatment of hepatitis C virus infection and implications of resistance to new direct-acting antiviral agents Genetic complementation of hepatitis C virus nonstructural protein functions associated with replication exhibits requirements that differ from those for virion assembly.Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication Charged residues in hepatitis C virus NS4B are critical for multiple NS4B functions in RNA replication.Identification of AP80978, a novel small-molecule inhibitor of hepatitis C virus replication that targets NS4B.A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens.A microfluidic platform for high-throughput multiplexed protein quantitation.The interaction between the hepatitis C proteins NS4B and NS5A is involved in viral replication Hepatitis C Viral Kinetics in the Era of Direct Acting Antiviral Agents and IL28B.Rapid, automated, parallel quantitative immunoassays using highly integrated microfluidics and AlphaLISA.

P2860

Q24297286-1A17F31F-4DB2-48BD-B799-8B5A84C1A63E Q24297412-E56DD26B-5045-4FAB-A374-DCA7844C5AD2 Q26781770-F7709279-D68F-4465-933C-B4C8DFEEDBF7 Q26991855-5E799F35-3759-4793-B809-A8B45A2CD5EF Q27022216-DD2C0C1C-7FEA-48AE-8C4D-632BD34BCC78 Q27487943-7A1D683B-2581-487E-A5A9-708529C67F54 Q27488432-116A1681-D9E2-444C-8BD0-57783FC32FA2 Q27488808-70DEA1F8-0A38-49DA-8E08-87728E18E847 Q27489811-71D1106D-EF75-4937-9962-FD3362C1D624 Q27490333-4AF3CE70-8A2E-4110-831C-D57233014CED Q27490426-7D43220C-A031-4795-84F8-5517BA9D20EA Q27490847-06B13393-4A2B-4E19-8B0D-BCD4030F285E Q27938491-BD91E352-AB54-470D-9680-7A9A41C4DFB0 Q30010631-17E1BD60-5150-42C7-97EB-8B1E65AA166B Q30418339-984A3F45-79DA-4DC6-80BC-3274C5A22487 Q30457639-3FEB3E81-F110-4795-B941-BCC2F9300D9A Q30572364-8E611599-2025-4834-892B-2ED29E444A0E Q33503986-00E6890F-25FB-4EDF-AA66-6F91A7BABC80 Q33980287-B50FCD17-412E-48AF-9ED0-16B57292D04F Q34036762-E926996A-CE85-4872-91C6-947CB2CCCA4A Q34054941-B48F8DA5-5CA4-4221-B7C2-FC99D19C4B63 Q34130399-C4F3CD93-A292-4AE6-8798-345631012D90 Q34168582-8C868B8D-B015-4298-9171-2FA72114C6C5 Q34235286-69DFE2BD-469A-4D3D-BB66-917DE321DC63 Q34447531-D5665DCA-8C2C-4662-9996-4B319F41BB2F Q34470890-81A73CB3-1424-4FD6-86B8-CBA2C5C8ED58 Q34620091-C69E07D0-69E9-43F7-8C00-651295441B20 Q34706484-EB7A10E4-0F1F-4CBF-9D94-855EA0F98136 Q34832146-8573C04E-0D7D-40CE-AAE7-2288C2089FD3 Q35018212-7A027A5C-3405-4D5B-8EEF-71D4A2DD7999 Q35026553-AAB5D4C0-46BE-44D8-B83D-6E2EDE9FDEDD Q35071597-268D6E2B-086D-401D-B991-AA17A4E82654 Q35077451-A2C42A37-F4D1-4D12-A527-72D2E408C7B9 Q35140442-E6806F17-1939-4D4D-A8FC-2AD3FACA925E Q35141547-60685F54-1E8C-4D08-9759-0B9B01F0F027 Q35186717-60F1150C-8AED-467E-9781-465BB398E04A Q35560994-49A7D215-245B-48CC-8D30-2B66A0E4C469 Q35597941-9F1EAAFD-34EC-4B14-AAD7-AF7C12D257DF Q35610571-4B42FE59-11FE-4AE5-B714-2CE223C54467 Q35740807-B35ECF4E-53E9-4A00-80D3-04B61EAD753F

P2860

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.

http://www.wikidata.org/entity/Q33946936

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Discovery of a hepatitis C tar ...... icrofluidic affinity analysis.

@ast

Discovery of a hepatitis C tar ...... icrofluidic affinity analysis.

@en

type

label

Discovery of a hepatitis C tar ...... icrofluidic affinity analysis.

@ast

Discovery of a hepatitis C tar ...... icrofluidic affinity analysis.

@en

prefLabel

Discovery of a hepatitis C tar ...... icrofluidic affinity analysis.

@ast

Discovery of a hepatitis C tar ...... icrofluidic affinity analysis.

@en

P1433

Q33946936-9EAD7915-4DC6-4A61-A495-CD1AFD3980C6

P1476

Q33946936-B3E1CE9C-AC8B-4A17-8058-72046167906E

P2093

Q33946936-32F1465E-734F-4906-A571-6E5A9EE2233E

Q33946936-4795BC9B-BC25-4F86-9045-7ADF98B25CD9

Q33946936-4CB7272D-1183-4078-9C60-B49DA8752015

Q33946936-58FAAE73-E7B4-47B7-8DF0-1D42DACAC304

Q33946936-956331DC-6061-4161-BAB3-0783812B6D14

Q33946936-B23D7DCD-C782-49F3-BAB8-A746E8589F68

Q33946936-E87032D8-955F-40D1-B30D-9706CBF5558F

P2860

Q33946936-00E66B64-BFDA-4EBF-A4ED-B2043C03AA11

Q33946936-0812A418-1A60-4D2F-9E49-0256BEF7A1D4

Q33946936-08963D43-D8B0-44E2-BACE-7704703114A5

Q33946936-090BE3F7-BBDA-48B7-89A2-B12EF92D58E7

Q33946936-132B5775-5815-482D-BCAF-717F6E453727

Q33946936-1C0A8A71-6DCE-4231-B608-0F30A249342E

Q33946936-210B5F78-D125-4A15-91CD-7F4E005C1201

Q33946936-2B58F63E-89F7-4A9A-880E-BE7262960B2F

Q33946936-326EA81C-DCFA-40B1-8822-D511B54EE494

Q33946936-34991B15-477B-49CD-8086-4AF5B9A38E4A

P2888

Q33946936-28A911A2-8FE5-4537-956F-CD5A333E4D5A

P304

Q33946936-FC58FA7B-E2AF-4F0F-B42C-AF098F76E649

P31

Q33946936-A535BEE8-F39B-4152-8530-29C2AEE63679

P356

Q33946936-10F907DF-1E14-485E-A2A0-EB43CC759D21

P433

Q33946936-9BDD6C04-269E-4F4E-843A-6D4021B1538E

P478

Q33946936-F193D7DC-0A89-427A-88DC-2821C0040664

P50

Q33946936-B9A155F8-EC94-4573-AD6D-A2613AF6966D

P577

Q33946936-3465E4CA-6531-47F8-BF2C-91239B994DEE

P5875

Q33946936-53397781-5DBB-4A51-B824-71BEE5889622

P6179

Q33946936-92F0E3EA-32C1-43C0-8EB5-AC8806F7C73C

P698

Q33946936-330DF095-120A-4E06-BD33-F5BAB156E4D9

P921

Q33946936-A36BF889-47D6-421F-86A4-EC6A034D36FC

P932

Q33946936-4A800217-DDD4-40E2-B9DA-9643DDEB6120

P356

P1433

Nature Biotechnology

P1476

Discovery of a hepatitis C tar ...... icrofluidic affinity analysis.

@en

P2093

Doron Gerber

http://www.w3.org/2001/XMLSchema#string

Ella H Sklan

http://www.w3.org/2001/XMLSchema#string

Jeffrey S Glenn

http://www.w3.org/2001/XMLSchema#string

Menashe Elazar

http://www.w3.org/2001/XMLSchema#string

Paul D Bryson

http://www.w3.org/2001/XMLSchema#string

Shirit Einav

http://www.w3.org/2001/XMLSchema#string

Stephen R Quake

http://www.w3.org/2001/XMLSchema#string

P2860

HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA

MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation

Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry

Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins

Topology of the Membrane-Associated Hepatitis C Virus Protein NS4B

Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

Amphipathic Helix-Dependent Localization of NS5A Mediates Hepatitis C Virus RNA Replication

Efficient initiation of HCV RNA replication in cell culture

Complete replication of hepatitis C virus in cell culture

P2888

P304

1019-1027

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NBT.1490

http://www.w3.org/2001/XMLSchema#string

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

26

http://www.w3.org/2001/XMLSchema#string

P50

Sebastian J Maerkl

P577

2008-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23224780

http://www.w3.org/2001/XMLSchema#string

P6179

1051305415

http://www.w3.org/2001/XMLSchema#string

P698

18758449

http://www.w3.org/2001/XMLSchema#string

P921

P932

4110250

http://www.w3.org/2001/XMLSchema#string