Analysis of ku80-mutant mice and cells with deficient levels of p53
about
The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiencyTwo faces of p53: aging and tumor suppressionDeletion of Ku70, Ku80, or both causes early aging without substantially increased cancerNon-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51.Accelerating aging by mouse reverse genetics: a rational approach to understanding longevityLoss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscleERCC1-XPF endonuclease facilitates DNA double-strand break repairGenetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and developmentDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsHIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cellsTissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.Pathologies associated with the p53 response.Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality.Trade-offs between cancer and other diseases: do they exist and influence longevity?Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseRemoving all obstacles: a critical role for p53 in promoting tissue renewalMuscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway.Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs.Does p53 affect organismal aging?Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice.The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis.The role of DNA breaks in genomic instability and tumorigenesis.The impact of altered p53 dosage on hematopoietic stem cell dynamics during agingThe role of the non-homologous end-joining pathway in lymphocyte development.Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification.H2AX haploinsufficiency modifies genomic stability and tumor susceptibilityStem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.BRCA1-Ku80 protein interaction enhances end-joining fidelity of chromosomal double-strand breaks in the G1 phase of the cell cycleOxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature agingDNA double-strand breaks: a potential causative factor for mammalian aging?DNA repair in murine embryonic stem cells and differentiated cellsTrade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity.Changes in the level and distribution of Ku proteins during cellular senescence.Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.
P2860
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P2860
Analysis of ku80-mutant mice and cells with deficient levels of p53
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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Analysis of ku80-mutant mice and cells with deficient levels of p53
@ast
Analysis of ku80-mutant mice and cells with deficient levels of p53
@en
type
label
Analysis of ku80-mutant mice and cells with deficient levels of p53
@ast
Analysis of ku80-mutant mice and cells with deficient levels of p53
@en
prefLabel
Analysis of ku80-mutant mice and cells with deficient levels of p53
@ast
Analysis of ku80-mutant mice and cells with deficient levels of p53
@en
P2093
P2860
P1476
Analysis of ku80-mutant mice and cells with deficient levels of p53
@en
P2093
P2860
P304
P356
10.1128/MCB.20.11.3772-3780.2000
P407
P577
2000-06-01T00:00:00Z