Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
about
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayPhosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinaseDNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formationFunctional and biochemical dissection of the structure-specific nuclease ARTEMISEme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cellsThe metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombinationDNA repair targeted therapy: The past or future of cancer treatment?Phosphorylation of Artemis following irradiation-induced DNA damage.Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis.The response to and repair of RAG-mediated DNA double-strand breaksNon-homologous end-joining, a sticky affairThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaksRad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stabilityDNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseSNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repairDNA double strand break repair enzymes function at multiple steps in retroviral infection.The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegansARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cellsHomozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndromeArtemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and developmentRegulation of the DNA Damage Response to DSBs by Post-Translational Modifications.Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation.XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.hSnm1B is a novel telomere-associated protein.Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.Proteasome activator PA200 is required for normal spermatogenesis.Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma.Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiencyDNA damage and L1 retrotranspositionChoosing the right path: does DNA-PK help make the decision?Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks.Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transferThe role of DNA breaks in genomic instability and tumorigenesis.Induced pluripotent stem cells are sensitive to DNA damage.Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.The role of the non-homologous end-joining pathway in lymphocyte development.
P2860
Q22065419-AAE7EB90-2870-4A32-8E99-33E339E02CBEQ24296672-B90A0FB7-114A-4F2B-A290-7EA45313B10FQ24559729-7ACB006B-8078-4438-87B4-1975A6BB2DC2Q24564574-E3D83B47-061E-47D8-8A93-33855ED01654Q24644518-FF6F92A1-24A7-45C8-9480-2942DBA07470Q24647735-3631A2E0-3D21-405A-91C6-C20491963458Q26768679-25C64E09-BAD9-48FD-8236-901308776DA9Q27919664-557AFC58-FE5B-43E3-9B7F-1732520A9E8EQ27919672-924A227B-2FAE-4890-811A-E614C4578A95Q27919681-9C2CD148-32F8-46E9-871D-D9649A96FD1DQ28256889-6C7D8363-2A4C-4100-B3ED-F2DD3DA372D9Q28260337-61C30BDD-812E-4AF6-82C6-E9B412D46F3CQ28296356-202879E8-7B01-4BC2-89FA-CA2BF00331B7Q28476006-851EF686-725F-4BD3-9281-C3B011F992B1Q28506612-E637CEC0-0A3E-4620-ACA7-FECFF9EC7CF9Q28511262-3968719F-BCF8-4875-9896-FFDFB38C9DC2Q28593511-989981E7-300C-444B-BC7F-09C295C79F2EQ30437599-C2437E41-3DC6-45F8-B87A-A0E7756F142AQ33506593-2863F0D0-685B-445E-96F9-7BFFC94A862DQ33729755-B886CFA9-B0C7-436E-98F0-F48DCC1AB1FFQ33733794-16F25849-22AD-428D-A53C-9664A3C0AA5DQ33850170-F6946399-C940-4846-B64D-8FE39608347BQ33886979-6509EADE-B12C-43D0-9E4D-286A50C3D8C4Q34186270-F5D06BA6-4D23-4F70-BE21-74B064FF1E24Q34211015-87C3DA89-7778-44CD-9A3C-5E4243FEE3E4Q34329896-14A7410E-15A2-41BC-8321-C2F7869E5715Q34512463-8359E914-5A5B-4EBE-B847-178719BBB75FQ34549990-F4690749-0CFD-4DEA-9870-53C81E070D23Q34563112-F38447B2-B555-44FF-A9A4-226E4C6CED43Q34568846-E8222B76-36F9-4740-93DE-AB7E5B129E20Q34999354-5D2F3503-3D5B-42BC-8D4E-A0E408AB1A74Q35016894-C9A13696-6AC3-40F4-B94E-B13EE4EC16B9Q35029335-09016A62-BD02-44BD-B28D-20C37B58EF45Q35030835-BEEF7A21-F788-4666-AE4C-EB0A6575278BQ35133845-417071D8-4498-4299-84C8-6CF3015FE293Q35170919-537C6771-174B-4C27-9C55-05EDF7E79E94Q35171927-DC9DDFF0-FC5E-47B5-B180-A16CFCA50619Q35604928-69E8BD32-68D1-49F3-B94F-997AC0163B4FQ35721509-8152EB9C-0CC5-468C-B769-204AB7C1EE22Q35830410-5AE3E1BE-8A03-4D19-8C0B-CB5A9FA25B21
P2860
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
description
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im März 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/03/03)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/03/03)
@nl
наукова стаття, опублікована в березні 2003
@uk
مقالة علمية (نشرت في 3-3-2003)
@ar
name
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@ast
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@en
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@nl
type
label
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@ast
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@en
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@nl
prefLabel
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@ast
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@en
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@nl
P2093
P2860
P3181
P356
P1476
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells
@en
P2093
David G. Schatz
David O. Ferguson
Frederick W. Alt
James Fleming
Mark Eckersdorff
Scott Whitlow
Sean Rooney
Sebastian Fugmann
P2860
P304
P3181
P356
10.1084/JEM.20021891
P407
P577
2003-03-03T00:00:00Z