The parasite-specific trypanothione metabolism of trypanosoma and leishmania. - Test2 - elhamkhani - TriplyDB

The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

http://www.wikidata.org/entity/Q33966094

about

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major Kinetics and redox-sensitive oligomerisation reveal negative subunit cooperativity in tryparedoxin peroxidase of Trypanosoma brucei brucei.Glyoxalase II of African trypanosomes is trypanothione-dependent.Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.Toxoplasma gondii excretory secretory antigenic proteins of diagnostic potential.Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.Trypanothione synthesis in crithidia revisited.In silico work flow for scaffold hopping in Leishmania Regulation of Leishmania (L.) amazonensis protein expression by host T cell dependent responses: differential expression of oligopeptidase B, tryparedoxin peroxidase and HSP70 isoforms in amastigotes isolated from BALB/c and BALB/c nude mice.Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase.Thiol-dependent peroxidases care little about homology-based assignments of function.Proteomic analysis of Trypanosoma cruzi epimastigotes subjected to heat shock.Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40.A thioredoxin family protein of the apicoplast periphery identifies abundant candidate transport vesicles in Toxoplasma gondii.Novel role of calmodulin in regulating protein transport to mitochondria in a unicellular eukaryote Structure-based ligand design and the promise held for antiprotozoan drug discovery.Arginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes.Polymeric colloidal particulate systems: intelligent tools for intracellular targeting of antileishmanial cargos.Identification of the nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi.Metabolic profiling framework for discovery of candidate diagnostic markers of malaria.Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes.Metabolism of two new benzodiazepine-type anti-leishmanial agents in rat hepatocytes and hepatic microsomes and their interaction with glutathione in macrophages.Improved orthologous databases to ease protozoan targets inference.Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite.Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism.PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.Monitoring of intracellular nitric oxide in leishmaniasis: its applicability in patients with visceral leishmaniasis.Iron enhances generation of free radicals by Artemisinin causing a caspase-independent, apoptotic death in Leishmania donovani promastigotes.Cloning, expression and dynamic simulation of TRYP6 from Leishmania major (MRHO/IR/75/ER).Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides.Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.Arginine and Polyamines Fate in Leishmania Infection.Trypanosomatid Infections: How Do Parasites and Their Excreted-Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

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P2860

The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

http://www.wikidata.org/entity/Q33966094

description

2003 nî lūn-bûn

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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2003 թվականի ապրիլին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

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The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

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The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

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The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

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The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

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The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

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Biological Chemistry

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The parasite-specific trypanothione metabolism of trypanosoma and leishmania.

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Heide Schmidt

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R Luise Krauth-Siegel

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Svea K Meiering

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P2860

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania

Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

Structures of tryparedoxins revealing interaction with trypanothione

X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution

The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADPH reduced state

Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation

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10.1515/BC.2003.062

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