Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. - Test2 - elhamkhani - TriplyDB

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.

http://www.wikidata.org/entity/Q33971668

about

Repurposing metformin: an old drug with new tricks in its binding pockets Fundamentals of cancer metabolism Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity Targeting mitochondria metabolism for cancer therapy Metabolic rewiring in melanoma ROS homeostasis and metabolism: a dangerous liason in cancer cells Anti-tumor activity of metformin: from metabolic and epigenetic perspectives Metabolic control of cancer cell stemness: Lessons from iPS cells Chemotherapy targeting cancer stem cells Metformin as a new anti-cancer drug in adrenocortical carcinoma Metformin Improves Diabetic Bone Health by Re-Balancing Catabolism and Nitrogen Disposal Cancer: fundamentals behind pH targeting and the double-edged approach Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats Dissecting the role of AMP-activated protein kinase in human diseases.Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches.Metformin and erlotinib synergize to inhibit basal breast cancer.Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions.Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality.Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer.Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling.AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition.mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors 5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits.Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.Metabolic requirements for cancer cell proliferation NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo.Quercetin modulates keratoconus metabolism in vitro Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice.Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies.Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis.Metformin enhances the radiosensitivity of human liver cancer cells to γ-rays and carbon ion beams.Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models.Metabostemness: a new cancer hallmark.The double-edged sword of AMPK signaling in cancer and its therapeutic implications.Sirtuins and the Metabolic Hurdles in Cancer.Drug repurposing in oncology--patient and health systems opportunities.

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P2860

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.

http://www.wikidata.org/entity/Q33971668

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Metformin and phenformin deple ...... and NTPs in cancer stem cells.

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Metformin and phenformin deple ...... and NTPs in cancer stem cells.

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Metformin and phenformin deple ...... and NTPs in cancer stem cells.

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Metformin and phenformin deple ...... and NTPs in cancer stem cells.

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Metformin and phenformin deple ...... and NTPs in cancer stem cells.

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Metformin and phenformin deple ...... and NTPs in cancer stem cells.

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Proceedings of the National Academy of Sciences of the United States of America

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Metformin and phenformin deple ...... and NTPs in cancer stem cells.

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Andreas Janzer

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John M Asara

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Karina N Gonzalez-Herrera

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Kevin Struhl

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Marcia C Haigis

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Natalie J German

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P2860

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

Investigating metformin for cancer prevention and treatment: the end of the beginning

Metformin in cancer: translational challenges

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10

Metformin and reduced risk of cancer in diabetic patients

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