Repurposing metformin: an old drug with new tricks in its binding pockets - Test2 - elhamkhani - TriplyDB

Repurposing metformin: an old drug with new tricks in its binding pockets

Repurposing metformin: an old drug with new tricks in its binding pockets

http://www.wikidata.org/entity/Q22250976

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Building for the future: essential infrastructure for rodent ageing studies Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity Metformin alters DNA methylation genome-wide via the H19/SAHH axis Metformin intake associates with better cognitive function in patients with Huntington's disease.Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells.Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice.Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice.Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.The stress polarity pathway: AMPK 'GIV'-es protection against metabolic insults.Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing.Metformin: clinical use in type 2 diabetes.Metformin Accelerates Glycolytic Lactate Production in Cultured Primary Cerebellar Granule Neurons.Metformin; a review of its history and future: from lilac to longevity.Metformin in pancreatic cancer treatment: from clinical trials through basic research to biomarker quantification.Hypothalamic AMPK: a canonical regulator of whole-body energy balance.Targeting adipose tissue in the treatment of obesity-associated diabetes.Nutritional strategies to optimise cognitive function in the aging brain.The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes.AMPK as a Pro-longevity Target.Metformin: New Preparations and Nonglycemic Benefits.Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms.Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway Metformin: a metabolic modulator.Effect of calcium electroporation in combination with metformin in vivo and correlation between viability and intracellular ATP level after calcium electroporation in vitro.Unhealthy smokers: scopes for prophylactic intervention and clinical treatment.Towards natural mimetics of metformin and rapamycin.Metformin-associated prevention of weight gain in insulin-treated type 2 diabetic patients cannot be explained by decreased energy intake: A post hoc analysis of a randomized placebo-controlled 4.3-year trial.Impaired Left Atrial Conduit Function in Coronary Artery Disease Patients With Poorly Controlled Diabetes: Two-Dimensional Speckle-Tracking Echocardiographic Study.Metformin: an anti-proliferative agent and methylation regulator in treating prostatic disease?Metformin use and health care utilization in patients with coexisting chronic obstructive pulmonary disease and diabetes mellitus.The effects of metformin on gut microbiota and the immune system as research frontiers.Functional organic cation transporters mediate osteogenic response to metformin in human umbilical cord mesenchymal stromal cells.Metabolic flexibility as an adaptation to energy resources and requirements in health and disease.Protective Effect of Metformin against Acute Inflammation and Oxidative Stress in Rat.Therapy of Type 1 Diabetes Mellitus

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P2860

Repurposing metformin: an old drug with new tricks in its binding pockets

http://www.wikidata.org/entity/Q22250976

description

2015 nî lūn-bûn

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2015 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Repurposing metformin: an old drug with new tricks in its binding pockets

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Repurposing metformin: an old drug with new tricks in its binding pockets

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Repurposing metformin: an old drug with new tricks in its binding pockets

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Repurposing metformin: an old drug with new tricks in its binding pockets

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Biochemical Journal

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Repurposing metformin: an old drug with new tricks in its binding pockets

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Rosina Pryor

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P2860

Mechanism by which metformin reduces glucose production in type 2 diabetes

Role of AMP-activated protein kinase in mechanism of metformin action

Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

AMPK phosphorylation of raptor mediates a metabolic checkpoint

The gut flora as a forgotten organ

Metformin activates AMP kinase through inhibition of AMP deaminase

Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver

Serine, glycine and one-carbon units: cancer metabolism in full circle

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307-322

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scholarly article

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1400601

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10.1042/BJ20150497

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3

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471

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Filipe Cabreiro

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2015-10-16T00:00:00Z

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2015-11-01T00:00:00Z

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283236575

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26475449

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type-2 diabetes

cardiovascular disease

maturity-onset diabetes of the young

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4613459

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