DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.
about
The transcription factor p53: not a repressor, solely an activatorP53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivationAn Integrative Analysis of Preeclampsia Based on the Construction of an Extended Composite Network Featuring Protein-Protein Physical Interactions and Transcriptional RelationshipsAccelerated cellular senescence phenotype of GAPDH-depleted human lung carcinoma cellsError-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasiaTumor suppression by p53: making cells senescent.SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage responseDeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiationUlcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma.DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase.Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein.Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation.ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway.RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant DefenseA gene signature-based approach identifies mTOR as a regulator of p73.Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality.Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.Werner syndrome through the lens of tissue and tumour genomics.Oncogene-induced senescence: an essential role for Runx.Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability.Senescence regulation by the p53 protein familyThe significance of the senescence pathway in breast cancer progression.A balancing act: orchestrating amino-truncated and full-length p73 variants as decisive factors in cancer progression.Transcriptome profiling of gill tissue in regionally bred and globally farmed rainbow trout strains reveals different strategies for coping with thermal stress.The transcription factor DEC1 (BHLHE40/STRA13/SHARP-2) is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells.Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism.Premature aging/senescence in cancer cells facing therapy: good or bad?The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytesTargeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases.p53 protein-mediated up-regulation of MAP kinase phosphatase 3 (MKP-3) contributes to the establishment of the cellular senescent phenotype through dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2).DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression.Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells.HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ΔNp63.p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stabilityThe increased expression of DEC1 gene is related to HIF-1α protein in gastric cancer cell lines.Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas.Ras activity levels control the development of pancreatic diseases.
P2860
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P2860
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
DEC1, a basic helix-loop-helix ...... ependent premature senescence.
@ast
DEC1, a basic helix-loop-helix ...... ependent premature senescence.
@en
type
label
DEC1, a basic helix-loop-helix ...... ependent premature senescence.
@ast
DEC1, a basic helix-loop-helix ...... ependent premature senescence.
@en
prefLabel
DEC1, a basic helix-loop-helix ...... ependent premature senescence.
@ast
DEC1, a basic helix-loop-helix ...... ependent premature senescence.
@en
P2093
P2860
P356
P1476
DEC1, a basic helix-loop-helix ...... ependent premature senescence.
@en
P2093
Bingfang Yan
Xinbin Chen
Yingjuan Qian
P2860
P304
P356
10.1074/JBC.M708624200
P407
P577
2007-11-19T00:00:00Z