Differential inhibitor sensitivity between human kinases VRK1 and VRK2. - Test2 - elhamkhani - TriplyDB

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

http://www.wikidata.org/entity/Q33988809

about

Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2 Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1 Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition.The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals.

P2860

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P2860

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

http://www.wikidata.org/entity/Q33988809

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

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Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

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type

label

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

@ast

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

@en

prefLabel

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

@ast

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

@en

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Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

@en

P2093

Iria Barcia-Sanjurjo

http://www.w3.org/2001/XMLSchema#string

Marta Sanz-García

http://www.w3.org/2001/XMLSchema#string

Marta Vázquez-Cedeira

http://www.w3.org/2001/XMLSchema#string

Pedro A Lazo

http://www.w3.org/2001/XMLSchema#string

Ramiro Barcia

http://www.w3.org/2001/XMLSchema#string

P2860

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer

Characterization of three paralogous members of the Mammalian vaccinia related kinase family

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells

Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

The protein kinase complement of the human genome

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

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e23235

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