A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase.
about
Thiamin diphosphate-dependent enzymes: from enzymology to metabolic regulation, drug design and disease modelsThe two active sites in human branched-chain alpha-keto acid dehydrogenase operate independently without an obligatory alternating-site mechanismMolecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylaseSnapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme ComplexUnexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiaminA dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase)BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium bergheiBranched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm)Phenylbutyrate therapy for maple syrup urine disease.A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complexModeling mitochondrial function.Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells.Acetohydroxyacid synthases: evolution, structure, and function.Local Alignment of Ligand Binding Sites in Proteins for Polypharmacology and Drug Repositioning.Determination of pre-steady-state rate constants on the Escherichia coli pyruvate dehydrogenase complex reveals that loop movement controls the rate-limiting step.Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families.Characterization of Autoantibodies against the E1α Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis.Lipoic acid metabolism and mitochondrial redox regulation.Discovering protein-ligand chalcogen bonding in the protein data bank using endocyclic sulfur-containing heterocycles as ligand search subsets.Structural insights into the mechanism of inhibition of AHAS by herbicides.
P2860
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P2860
A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A versatile conformational swi ...... alpha-ketoacid dehydrogenase.
@ast
A versatile conformational swi ...... alpha-ketoacid dehydrogenase.
@en
type
label
A versatile conformational swi ...... alpha-ketoacid dehydrogenase.
@ast
A versatile conformational swi ...... alpha-ketoacid dehydrogenase.
@en
prefLabel
A versatile conformational swi ...... alpha-ketoacid dehydrogenase.
@ast
A versatile conformational swi ...... alpha-ketoacid dehydrogenase.
@en
P2093
P50
P1433
P1476
A versatile conformational swi ...... alpha-ketoacid dehydrogenase.
@en
P2093
David T Chuang
Jacinta L Chuang
R Max Wynn
Ronald Kluger
P304
P356
10.1016/J.STR.2005.10.009
P577
2006-02-01T00:00:00Z