about
Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenasep31comet blocks Mad2 activation through structural mimicryRoles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active siteMolecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylationStructural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loopsCrystal structure of a 12 ANK repeat stack from human ankyrinR.Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complexMunc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosisCrystal structure of the RIM1alpha C2B domain at 1.7 A resolutionStructural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switchThree-dimensional structure of the complexin/SNARE complexCrystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding proteinKinetic stabilization of Bacillus licheniformis alpha-amylase through introduction of hydrophobic residues at the surfaceMonovalent cation dependence and preference of GHKL ATPases and kinasesCrystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrinStructural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteasesThe two active sites in human branched-chain alpha-keto acid dehydrogenase operate independently without an obligatory alternating-site mechanismStructural basis of histone demethylation by LSD1 revealed by suicide inactivationStructural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamineStructural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine ReceptorInteractions of substrates at the surface of P450s can greatly enhance substrate potencyCrystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channelInsights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 DimerChanges at the KinA PAS-A dimerization interface influence histidine kinase functionCrystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator fromBacillus subtilisreveal ligand-induced structural changes upon binding of several glycolytic intermediatesStructure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1Localization and Structure of the Ankyrin-binding Site on 2-SpectrinArtificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factorStructure and Mechanism of a Eukaryotic FMN AdenylyltransferaseStructural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1Crystal Structure of the Formin mDia1 in Autoinhibited ConformationStructural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein Subunit MutantsThe crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation.Computational Design of the Sequence and Structure of a Protein-Binding PeptideA Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product FormationHeterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolyticaMetal-Mediated Affinity and Orientation Specificity in a Computationally Designed Protein HomodimerComputational design of a symmetric homodimer using -strand assemblyIncreasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic CoreDiscovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Mischa Machius
@ast
Mischa Machius
@en
Mischa Machius
@es
Mischa Machius
@sl
type
label
Mischa Machius
@ast
Mischa Machius
@en
Mischa Machius
@es
Mischa Machius
@sl
prefLabel
Mischa Machius
@ast
Mischa Machius
@en
Mischa Machius
@es
Mischa Machius
@sl