Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA
about
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesisStructures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug actionRevisiting the structures of several antibiotics bound to the bacterial ribosomeThe bacterial ribosome as a target for antibioticsNewer antibacterial drugs for a new century.Molecular basis of intrinsic macrolide resistance in clinical isolates of Mycobacterium fortuitum.Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implicationsEffects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor.Pneumococcal resistance to macrolides, lincosamides, ketolides, and streptogramin B agents: molecular mechanisms and resistance phenotypes.Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cellsReverse engineering antibiotic sensitivity in a multidrug-resistant Pseudomonas aeruginosa isolateTreatment efficacy, treatment failures and selection of macrolide resistance in patients with high load of Mycoplasma genitalium during treatment of male urethritis with josamycinNovel antibacterial agents for the treatment of serious Gram-positive infections.Role of antibiotic ligand in nascent peptide-dependent ribosome stallingIsolation of translating ribosomes containing peptidyl-tRNAs for functional and structural analysesRibosomal features essential for tna operon induction: tryptophan binding at the peptidyl transferase center.Crucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function.Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.The ribosomal peptidyl transferase center: structure, function, evolution, inhibition.Proteomic analysis of tylosin-resistant Mycoplasma gallisepticum reveals enzymatic activities associated with resistance.Species-specific antibiotic-ribosome interactions: implications for drug development.Antibiotics and the ribosome.Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan.Mutations Associated with Decreased Susceptibility to Seven Antimicrobial Families in Field and Laboratory-Derived Mycoplasma bovis StrainsStrategies for the design of RNA-binding small molecules.The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.Animal models of hepatotoxicity.Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.Toward the rational design of macrolide antibiotics to combat resistance.Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin.Resistance to Macrolide Antibiotics in Public Health Pathogens.Insights into the mode of action of novel fluoroketolides, potent inhibitors of bacterial protein synthesisThe macrolide antibiotic renaissance.Mutations in 23S rRNA account for intrinsic resistance to macrolides in Mycoplasma hominis and Mycoplasma fermentans and for acquired resistance to macrolides in M. hominis.Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.In vitro activities of novel 2-fluoro-naphthyridine-containing ketolidesBinding site of the bridged macrolides in the Escherichia coli ribosome.Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible.Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity.Fluorescence polarization method to characterize macrolide-ribosome interactions
P2860
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P2860
Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Binding site of macrolide anti ...... raction of ketolides with rRNA
@ast
Binding site of macrolide anti ...... raction of ketolides with rRNA
@en
type
label
Binding site of macrolide anti ...... raction of ketolides with rRNA
@ast
Binding site of macrolide anti ...... raction of ketolides with rRNA
@en
prefLabel
Binding site of macrolide anti ...... raction of ketolides with rRNA
@ast
Binding site of macrolide anti ...... raction of ketolides with rRNA
@en
P2093
P2860
P1476
Binding site of macrolide anti ...... raction of ketolides with rRNA
@en
P2093
P2860
P304
P356
10.1128/JB.183.23.6898-6907.2001
P407
P577
2001-12-01T00:00:00Z