Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action
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Potential key bases of ribosomal RNA to kingdom-specific spectra of antibiotic susceptibility and the possible archaeal origin of eukaryotesRNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shiftBinding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesisRibosomal Antibiotics: Contemporary ChallengesChloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current SolutionsPost-translational hydroxylation by 2OG/Fe(II)-dependent oxygenases as a novel regulatory mechanism in bacteriaResistance to linezolid caused by modifications at its binding site on the ribosomeAcquired inducible antimicrobial resistance in Gram-positive bacteriaStructural basis for the function of a small GTPase RsgA on the 30S ribosomal subunit maturation revealed by cryoelectron microscopyDissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly processA dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.The structural basis for substrate versatility of chloramphenicol acetyltransferase CATIStructure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNAStructural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptideStructural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPaseThe structure of Rv2372c identifies an RsmE-like methyltransferase from Mycobacterium tuberculosisThe proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complexStructural basis for specific recognition of single-stranded RNA by Toll-like receptor 13Targeting Antibiotic ResistanceImpact of ribosomal modification on the binding of the antibiotic telithromycin using a combined grand canonical monte carlo/molecular dynamics simulation approachSynthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cellsReduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibioticsStructural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence.Macrolide antibiotics allosterically predispose the ribosome for translation arrest.Structural basis for the interaction of protein S1 with the Escherichia coli ribosome.Phylogeny and molecular signatures for the phylum Thermotogae and its subgroups.Designer drugs for discerning bugs.Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation.Investigational antimicrobial agents of 2013.The evolving role of chemical synthesis in antibacterial drug discovery.A docking-based receptor library of antibiotics and its novel application in predicting chronic mixture toxicity for environmental risk assessment.Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.The general mode of translation inhibition by macrolide antibioticsMacrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome.Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.Recruitment of a species-specific translational arrest module to monitor different cellular processes.Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain.Role of antibiotic ligand in nascent peptide-dependent ribosome stallingZn(II) binding to Escherichia coli 70S ribosomes
P2860
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P2860
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action
description
2010 nî lūn-bûn
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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Structures of the Escherichia ...... explain spectra of drug action
@ast
Structures of the Escherichia ...... explain spectra of drug action
@en
Structures of the Escherichia ...... explain spectra of drug action
@nl
type
label
Structures of the Escherichia ...... explain spectra of drug action
@ast
Structures of the Escherichia ...... explain spectra of drug action
@en
Structures of the Escherichia ...... explain spectra of drug action
@nl
prefLabel
Structures of the Escherichia ...... explain spectra of drug action
@ast
Structures of the Escherichia ...... explain spectra of drug action
@en
Structures of the Escherichia ...... explain spectra of drug action
@nl
P2093
P2860
P3181
P356
P1476
Structures of the Escherichia ...... explain spectra of drug action
@en
P2093
Alexander S Mankin
Jack A Dunkle
Jamie H D Cate
Liqun Xiong
P2860
P304
P3181
P356
10.1073/PNAS.1007988107
P407
P577
2010-10-05T00:00:00Z