11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux. - Test2 - elhamkhani - TriplyDB

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux.

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux.

http://www.wikidata.org/entity/Q34010493

about

Small and Innovative Molecules as New Strategy to Revert MDR PET radiotracers: crossing the blood-brain barrier and surviving metabolism Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies.Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice.P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier Avoiding barriers to PET radioligand development: cellular assays of brain efflux transporters Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET P-glycoprotein-based loperamide-cyclosporine drug interaction at the rat blood-brain barrier: prediction from in vitro studies and extrapolation to humans.Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo.In vivo evaluation of limiting brain penetration of probes for α(2C)-adrenoceptor using small-animal positron emission tomography.In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice.Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy.Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys.Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach On quantitative relationships between drug-like compound lipophilicity and plasma free fraction in monkey and human.Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications.Drug interactions at the blood-brain barrier: fact or fantasy?Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.In vitro, in vivo and in silico models of drug distribution into the brain.Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.Positron emission tomography radioligands for the opioid system.Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on "humanized" animal models.Radiopharmaceuticals for assessing ABC transporters at the blood-brain barrier.Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.Discrepancies in the P-glycoprotein-mediated transport of (18)F-MPPF: a pharmacokinetic study in mice and non-human primates.Toward an improved prediction of human in vivo brain penetration.Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein.

P2860

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P2860

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux.

http://www.wikidata.org/entity/Q34010493

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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JNUMED.107.047308

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The Journal of Nuclear Medicine

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11C-loperamide and its N-desme ...... meability-glycoprotein efflux.

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Edward Tuan

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Fumihiko Yasuno

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Jeih-San Liow

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Jinsoo Hong

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Neva Lazarova

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Robert B Innis

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Robert L Gladding

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Sami S Zoghbi

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Victor W Pike

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649-656

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4

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49

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