Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

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Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions.

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Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

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2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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Imaging P-glycoprotein function in rats using [

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Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

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type

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Imaging P-glycoprotein function in rats using [

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Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

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Imaging P-glycoprotein function in rats using [

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Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

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P1476

Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

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P2093

Balu Easwaramoorthy

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Derek J Chong

http://www.w3.org/2001/XMLSchema#string

Masanori Ichise

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Michael D Farwell

http://www.w3.org/2001/XMLSchema#string

Sung A Bae

http://www.w3.org/2001/XMLSchema#string

Yasuhiko Iida

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P2860

Mechanisms of cancer drug resistance

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus.

P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.

N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux.

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.

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s12149-013-0725-5

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618-624

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scholarly article

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10.1007/S12149-013-0725-5

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2013-04-10T00:00:00Z

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236188735

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23572210

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Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

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P2860

P2860

Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

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P1476

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P698